271 results
The main objective of the trial is to show that ABVD-based response-adapted therapy for advanced-stage Hodgkin lymphoma, with treatment intensification (BEACOPP) in case of a positive FDG-PET after one cycle of ABVD, has non-inferior efficacy…
The primary objective is to evaluate possible clinical effects correlated with α3β1 and CD151 expression in human epidermal malignancies, and relate these findings to the effects of α3β1 and CD151 deficiencies in skin cancer in the mouse.…
The overall goal of this study is to further validate and improve the sentinel node procedure for prostate cancer using ICG-99mTc-nanocolloid. The first objective aims at further validation of the sentinel node procedure for prostate cancer via…
Little research is being done on the effects of psychological treatment in patients with a bipolar disorder (BD) and comorbide borderline personality disorder (BPD) features. There are no recommendations included in the guideline for BD (Nolen et al…
The aim of the present study is to study Metvix® photodynamic therapy (MAL-PDT) of superficial basal cell carcinoma (sBCC) using two light fractions with one or two hours interval: comparison of illumination at 3 (20 J/cm2) and 4 hours (55 J/cm2)…
To this end, two study protocols have been developed, one concerning the *target group* of overweight children (aged 12-16), only including non-invasive measurements, and one targeting adult overweight participants (aged 18-45), allowing for…
The purpose of this study is to determine how diagnostic delay of CD affects the burden of CD to patients and society in terms of healthcare and mental healthcare utilisation and socioeconomic costs.
We aim to identify biomarkers (from neuroimaging, eye tracking, EEG, cognition, biochemistry, proteomics, genomics) for stratification of ASD. Biomarkers will be crucial to aid more accurate and earlier diagnosis of ASD. They are also needed for…
We want to investigate wether a para-vertebral block contributes to a reduced postoperative pain and morphine consumption in patients with breast cancer after a unilateral mastectomy or lumpectomy. By doing this investigation we hope to clarify,…
•To characterize the natural history and progression of DMD to help inform the design of future studies•To capture biomarkers of safety and disease progression•To provide comparative data for the development of rare exons for which formal controlled…
We study training effects in patients that receive training in the early CVA-phase (CVA < 6 weeks).Goals:1. Determination of the training effects in the early phase of stroke. 2. Determination of quality of life in trained CVA patients with…
Primary Objective The objective of this study is to evaluate the extent of neointima formation at 3 month after (successful) implantation of the Nano+ stent in a single lesion in elective PCI patients. Secondary Objective To assess if NanoTM Polymer…
The family with the TRα2 premature stop enables us to investigate the biological role of the orphan wild-type TRα2 and the consequences of its dysfunction. The primary objectives of this proposal are (i) to search for a biological function of TRα2…
Main Objective: - to validate the identified cognitive profiles prospectively in a new population using confirmatory cluster analysisSecondary Objectives: - to identify the clinical and demographical factors associated to the identified cognitive…
Predicting fluid responsiveness during PLR and fluid challenge (FC) by changes in (Pms).
The present study aims to determine the bioavailability of hesperidin when micronized and non-micronized, when S-enantiomeric enriched and racemic, and when incorporated in a lozenge compared to a capsule, such that the appropriate dosage form can…
The purpose of this observational study is to investigate the adherence during 2 months in adolescents with type 1 diabetes on subcutaneous insulin pump therapy. The main outcome measure will be the amount of insulin bolusses and glucose…
To investigate the risk of deeath and incident (cardio)vascular disease in patients with a TIA or stroke aged 18-50 yearsTo investigate the riks of cognitive impairment and (vascular) dementia in patients with a TIA or stroke aged 18-50 yearsTo…
The overall aim of this study is to investigate interoceptive conditioning of fear and it*s generalization in both panic/anxiety patients and healthy control subjects. Therefore we have three specific objectives. The first objective is to replicate…
In deze studie zal de nauwkeurigheid van peroperatieve meting van de cuppositie door een nieuw ontworpen, onlangs gepatenteerd, meetinstrument worden onderzocht. In de toekomst kan, indien het meetinstrument betrouwbaar blijkt, peroperatief de…