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Prevention of relapses with Levamisole as adjuvant therapy to corticosteroids in children with first episode of idiopathic nephrotic syndrome.

This study has been transitioned to CTIS with ID 2024-517467-23-00 check the CTIS register for the current data. Primary objective: - To investigate the effect of additional levamisole in comparison with placebo from 4 weeks to 6 months after the…

Multi-Center Clinical Evaluation of the ATTUNE® Revision System in Revision Total Knee Arthroplasty

There are two, co-primary objectives; one regarding each tibial component FB or RP:1) To evaluate the 5 year survivorship using Kaplan-Meier survival analysis, with revision for any reason as the endpoint, for the ATTUNE® Revision TKA PS FB…

Effectiveness of total extraperitoneal hernia correction for clinically occult inguinal hernia: a multicenter randomized controlled trial

To evealuate the (cost-)effectiveness of endoscopic totally extraperitoneal (TEP) inguinal hernia correction comparecd to watchful waiting in patients with groin pain and a clinically occult inguinal hernia.

A randomized, open-label phase II/III study with dendritic cells loaded with allogeneic tumour cell lysate (PheraLys) in subjects with mesothelioma as maintenance treatment (MesoPher) after chemotherapy

The primary objective of this study is to evaluate the overall survival (OS) rate (determined from the time of randomization in the study) of subjects who receive dendritic cell immunotherapy with MesoPher plus best supportive care (BSC) compared to…

How does pneumatic tube transportation of thrombocyteconcentrates for transfusion purposes influence the thrombocyte in vivo function?

Aim of the study is to show the feasibility of pneumatic tube transport of thrombocyte concentrates. The efficacy will be measured by thrombocyte increment (CCI) and thrombocyte funtion analysis. This shall lead to routine transportation of TC*s to…

Beating EATL - towards rationally targeted therapy for enteropathy-associated T-cell lymphoma

The purpose of this project is to provide a rational basis for the selection of small-molecule inhibitors that block the signalling of all cytokines involved in type I enteropathy-associated T cell lymphoma (type I EATL).

Examining brain phenotypes in carriers of (common) mutations in Polymerase gamma (PolG) using 7T MRI imaging.

I) To apply MRI techniques to identify anatomical and functional POLG related cerebral biomarkers. II) Investigate differences in said biomarkers between subjects and healthy controls.

Amyloid pathology in cognitively normal elderly subjects

This study has been transitioned to CTIS with ID 2024-518559-41-01 check the CTIS register for the current data. The main objectives are to identify markers for amyloid pathology in cognitively normal subjects, to identify risk factors for amyloid…

Development of Dendritic Cell vaccines as future treatment of patients with cancer

The proposed research is part of our ongoing research of the last 17 years. Development of immunotherapy for cancer is our main theme and DC vaccines is our oldest program and play a crucial role.At this moment still 40% of cancer patients die of…

Effectiveness of different strengths of topical steroids: providing evidence for a better treatment strategy in children with atopic dermatitis in general practice.

To determine whether a potent topical CS is more effective than a mild topical CS in the treatment of children with a moderate flare-up of atopic dermatitis in primary care on short and long term.

DCOG-iTHER: Towards Individualized Therapies for Children with Relapsed/Refractory Malignancies using Molecular Profiling

To analyse the number of patients with (germline/somatic) actionable molecular aberrations in patients with relapsed/refractory pediatric tumors for whom no standard treatment or study protocol is available.

The development of electrophysiological readouts for migraine attack prediction

The overall objective of this study is to combine a conceptual model with empirical evidence to demonstrate that the start of a migraine attack corresponds to a critical transition that occurs when the dynamical brain system approaches a tipping…

The Dynamic interplay between bleeding phenotype and baseline factor level in moderate and mild hemophilia A and B

The primary aim of this project is to analyze the association between factor VIII and factor IX plasma levels and the bleeding phenotype.

Blended versus face-to-face Cognitive Behavioural Therapy in treating severe fatigue in patients with MS - an observer-blinded randomized clinical trial testing non-inferiority at post-treatment and long-term effectiveness.

1. To investigate the non-inferiority of blended CBT compared to proven effective face-to-face CBT according to the TREFAMS-CBT treatment protocol in severely fatigued patients with MS, using a non-inferiority margin of 5.3 points on the Checklist…

Protein-specific turnover in the human brain; Measuring protein-specific synthesis rates of the human brain using the D2O dosing method

To assess protein-specific synthesis rates neocortex, hippocampus, temporalis muscle, and vastus lateralis muscle using the D2O dosing method.

A Prospective, Non-randomized, Consecutive Series, Multicenter, Post-Market Study to Evaluate the Clinical Outcome of Total Knee Arthroplasty Using Journey II BCS Total Knee System

The purpose of this study is to document the short-, mid- and long-term safety and efficacy of the Journey II BCS knee prosthesis. The goal of this study is to confirm the safety and efficacy of the Journey II BCS knee prosthesis by demonstrating…

Phase 3 Study Comparing Daratumumab, Lenalidomide, and Dexamethasone (DRd) vs Lenalidomide and Dexamethasone (Rd) in Subjects With Relapsed or Refractory Multiple Myeloma

The primary objective is to compare the efficacy of daratumumab when combined with lenalidomide and dexamethasone (DRd) to that of lenalidomide and dexamethasone (Rd), in terms of progression-free survival (PFS) in subjects with relapsed or…

A Phase 3 Randomized, Multicenter Study of Subcutaneous Daratumumab Versus Active Monitoring in Subjects with High-risk Smoldering Multiple Myeloma

This study has been transitioned to CTIS with ID 2023-507143-11-00 check the CTIS register for the current data. Primary objective: To determine whether treatment with daratumumab administered subcutaneously (SC) prolongs progression-free survival (…

A Phase IIb, prospective, intra-patient randomised controlled, multicentre study to evaluate the safety and efficacy of an autologous bio-engineered dermo-epidermal skin substitute (EHSG-KF) for the treatment of partial deep dermal and full thickness burns in adults and adolescents in comparison to autologous split-thickness skin grafts (STSG)

This study has been transitioned to CTIS with ID 2024-512188-29-00 check the CTIS register for the current data. To evaluate the efficacy and safety of EHSG-KF in comparison to meshed STSG in adults and adolescents with partial deep dermal and full…

Immunogenicity of Tumor Organoids derived from colorectal, gastric, gynaecological and non-small cell lung cancer, a Feasibility Study

Establish the immunogenicity of tumor organoids in vitro