1363 results
Primary objectives Phase I: To determine the recommended phase 2 dose (RP2D) of the lapatinib-trametinib combination in patients with KRASm NSCLC Phase II: To determine the progression free survival of the lapatinib-trametinib combination compared…
We propose to investigate the effect of administering a broad-acting, potent immune suppressive agent early in the course of the disease as this may prevent neuronal damage caused by low-grade inflammatory processes in the brain. It is expected that…
The objective of this study is to determine whether monomeric and oligomeric flavanols have a beneficial effect on renal-endothelial function in the dietary management of T2D, as reflected by improvement of AER and renal-endothelial biomarkers
The primary objective of this study is to investigate the safety of systemic administration of AAV5-hFIX, an adeno-associated viral vector containing a codon-optimized hFIX gene, to adult patients with severe or moderately severe haemophilia B.…
The rationale for performing this clinical study is to gather clinical data to evaluate the safety and effectiveness of the NUsurface device compared to the Standard of Care.
Primary objective To determine the MTD and/or to identify the RDE of HDM201 in one or more of the pre-defined regimensSecondary objectives * To characterize the safety and tolerability of HDM201* To characterize the pharmacokinetic (PK) properties…
Part 1: Determine the Recommended Phase II Dose
In this study we will identify the role of the endothelial GAGs in Na+ and volume homeostasis. Is there a link between the ESL and individual susceptibility to Na+-excess?
To evaluate the effect of beta 3 adrenoreceptor agonist on urethral pressure variations during filling phase and to initially explore the possibilities for individualisation of treatment for overactive bladder symptoms.
The primary outcome is to assess carotid artery plaque constitution in terms of intraplaque hemorrhage and plaque burden (thickness) as measured with 3T MRI in both hemophilia patients and control patients
The objective of this study is to evaluate the performance and safety of the Cardioband Adjustable Annuloplasty System for repair of functional mitral regurgitation.
The primary objective is to determine if metastatic breast cancer patients with HER2-negative primary tumors but with at least one HER2-positive CTC benefit from trastuzumab-containing chemotherapy. Secondary objectives are to determine the impact…
Therapeutic drug monitoring is effective in optimizing treatment with tobramycin and reduces side effects.
Primary Objective: The primary objective of this study is to evaluate the difference in functional outcome, measured by the Constant Murley Scale at six weeks, three months, six months and one year, after treatment with high-energy ESWT versus US-…
Consumption of the new developed GUM will decrease the incidence of upper respiratory tract infections (URTI) and/or decrease the duration of acute gastrointestinal tract infections (GITI) in Asian toddlers
Two hours of end-ischemic hypothermic oxygenated perfusion via both the hepatic artery and the portal vein is feasible and safe in resuscitating liver grafts procured from donation after circulatory death donors.
Aims: 1. To determine the prevalence of subjective sleep disturbances and the influence on quality of life in people with epilepsy compared to people without epilepsy 2. To explore the factors which contribute to sleep disturbances in people with…
The hypothesis to be tested is that arm B is tolerable and that the outcome in arm B is better than in arm A.
Type 2 diabetes is a major threat to human health. Disruption of the circadian timing system is associated with metabolic changes. Disturbance of the daily light and dark rhythm could contribute to this phenomenon and effects metabolic pathways. We…
The objective of this study is to describe a pharmacokinetic profile of total and unbound plasma concentrations ropivacaine, when used for local infiltration analgesia in total knee arthroplasty