1046 results
The objectives are to study short-term changes in lung function, exhaled NO, respiratory symptoms and bronchodilator medication use in association with short-term changes in UFP in general and UFP from aircraft emissions specifically in children…
The purpose of this study is to find out which common problems occur in the HME patient population. Furthermore the study will investigate which factors are associated with the observed problems. This is barely investigated in the current literature…
To investigate acute effects of a single 40 mg dose hydrocortisone, compared with placebo, on stress and various aspects of attention and other cognitive processing of emotionally relevant stimuli in healthy anxious young females. The main question…
The primary objective of this study is to investigate the acute effects of a Breinspijs meal on the cognitive domains attention, processing speed, working memory and episodic memory. Secondary objectives are the effects of a Breinspijs meal on…
to evaluate the feasibility and usability of a brief dementia screening instrument for primary care setting
1. To develop a Dutch version of the FCU, adapted to the Dutch cultural context and target group of youth with psychological and/or behavioral problems in regular and special education2. To evaluate the implementability of the FCU in the Netherlands…
Our primary objective is to identify the disturbances in prosody, phonation and articulation with which dysarthria can be automatically recognized in speakers of Dutch, and German. To this end, we will first perform an experiment that involves the…
In this study we use a unique paradigm which can be used to examine both high-level (serial dependence) effects as low-level (adaptation) effects. By doing so we hope to resolve the discrepancy in the previous findings. We expect that low-level…
Is the performance on pretreatment exposure, assessed by the BAT-procedure, related to symptom change after 12 weeks of specialized clinical CBT, in patients with Obsessive-Compulsive Disorder?
The goal of this study is to analyse the effect and safety of PTNS in 20 children with persistent overactive bladder complaints refractory to standard treatment
To obtain a comprehensive overview of long-term (*5 years after burn injury) consequences after burn injuries, both in all patients admitted to burn centre admissions and in a subgroup of patients who suffered from more extensive burns.
To investigate whether long-term activation of the innate immune system, named *trained innate immunity*, occurs at the level of the bone marrow progenitor cells in patients with significant coronary artery disease and whether this correlates with…
Study I aims to explore dysregulation of biological stress systems among traumatized youths with and without ID in residential care, and compare them with a healthy control group. Study II aims to conduct a randomized controlled trial (RCT) to test…
To investigate the long term (ten years) protective immune response to fractional yellow fever vaccination (1/5th of the standard dose, injected intradermally), compared to the standard subcutaneous vaccination
The main objective is to compare the efficacy and safety of esophageal dilation with the balloon the Savary bougie dilator according to the rule-of-3 to rule-of > 3 strategy during 6 months in patients with a severe benign esophageal…
PrimarySafety and tolerability of MVT-602 following single dose subcutaneous administration in healthy premenopausal womenSecondaryPharmacokinetics (PK) and pharmacodynamics (PD) of MVT-602 following single dose subcutaneous administration
Our primary objective is to identify de novo/rare mutations causative of MS using WES in members of multi-incident families. Our secondary objective is to describe phenotypes per family using questionnaires and semi-structured interviews with family…
The purpose of this study is to investigate how safe the new compound FLX475 is when it is administered to healthy subjects. FLX475 has not been administered to humans before. It has been previously tested in the laboratory and on animals. FLX475…
To generate a set of normal values in people over 60 that can be expected to have an normal immune system, in order to be able to interpret the immune system of eldery patients with repeated airway infections.
The aim of the project is to study the effect of COM test compounds on typical skin features of psoriasis. This information can establish the most effective compound, right formulation and dose for further clinical research.