37 results
The standard-of-care sentinel lymph node (SLN) procedure in paediatric cancer patients consists of a preoperative intradermal injection with 99mTechnetium-nanocolloid as radiotracer in combination with an intraoperative injection of blue dye for…
The main objective is to pinpoint the biological pathways that set long-term risk of CVD and NDI when epigenetically disturbed during fetal development by (1) establishing a longitudinal cohort of MC twins, (2) defining epigenetic alterations…
The primary objectives of this study are:1. to investigate the association between both conventional and alternative coagulation tests, and hemostatic complications, including bleeding and clotting complications in pediatric ECMO patients2. to…
Primary ObjectiveThe primary objective of this study is to examine the feasibility of using the clubfoot brace. This will be done by recording the effect of the brace on the clubfoot deformity by determining the improvement of the Dimeglio and…
To survey the clinical and biochemical characteristics of individuals diagnosed with OCTN2, CPT2, CACT or BKT deficiency or suspected with OCTN2 deficiency after NBS in the Netherlands to aid the decision on whether or not to include these disorders…
This study has been transitioned to CTIS with ID 2023-504999-25-00 check the CTIS register for the current data. To investigate wether the treatment of children and adolescents with AML can be improvedby means of:1) improved risk-group adapted…
To measure cardiac output at various levels of Positive End Expiratory Pressure (PEEP).
The objective of this study is to further unravel the complexity of human milk and its variations over lactation stages and between individuals.
Primary Objective: to develop and evaluate a machine learning (ML) prediction model of brain injury in neonates at high-risk for CP to predict motor, behavioral, and cognitive outcome more accurately.This aim will be achieved by: developing and…
Main objective : To develop a spleen examination dedicated to overweight or obese patients and assessits applicability.Secondary objectives :1. Develop a spleen exam dedicated to patients usually measured with the S+ probe and assess its…
Primary:Evaluate the impact of SoC anemia management on Hgb concentrationsSecondary:- Characterize the use of ESA therapies in management of anemia associated with moderate to severe CKD in children and adolescents aged <18 years- Evaluate…
Demonstrate the suitability of cardiorespiratory monitoring directly after birth using a novel, wireless, non-adhesive device.
This study has been transitioned to CTIS with ID 2024-510742-13-00 check the CTIS register for the current data. The primary objective is to compare the objective response rate (ORR) assessed per Response Assessment in Neuro Oncology for low-grade…
The aim of this study is to compare the outcome of a clinical challenge test and home introduction of cow*s milk for children with a suspected non-IgE-mediated cow*s milk allergy. We want to evaluate the ability of both tests to determine the…
Objectives: 1) Create shared and disease-specific developmental curves with relevant and meaningful outcomes in children with brain-related disorders. 2) Develop innovative paradigms and parameters from neurophysiological, brain structure and motor…
The main objective is to research the practicability of postoperative fLTB through the endotracheal tube, right before/during planned extubation in the intensive care unit (ICU) in newborn babies after EA correction.
The purposes of this study are to uncover1. Which surgical methods are least likely to cause the CMS and if there is a difference in risk between primary surgery andreoperation2. Which patients may be genetically predisposed to developing the CMS 3…
This study has been transitioned to CTIS with ID 2023-508101-24-00 check the CTIS register for the current data. The primary objective of the first randomized question (R1) open for allLBL patients (pts) of the core study cohort, is to evaluate…
The overall aim of the SIOP 2016 UMBRELLA protocol is to harmonize the clinical relevant standarddiagnostic procedures for all paediatric renal tumours within SIOP and to provide imaging studies andbiomaterial from all of these patients, to find new…
Primary objective: To improve outcome prediction in sFGR by developing a prediction model at the time of sFGR diagnosis and by evaluating specific ultrasound parameters throughout the pregnancy. Secondary objectives: - To increase our knowledge of…