Search for a trial

The long-term effects of Small Vessel Disease

Primary ObjectiveOur primary objective is to investigate the effect of SVD-progression on the long-term clinical outcome. Secondary Objectives- To identify causes and risk factors related to an unfavourable clinical outcome over time- To identify…

A single-center, randomized, double-blind, double-dummy, placebo- and active-controlled, 4-way cross-over study to assess next-day driving performance following single and multiple evening administrations of ACT-541468 in middle-aged and elderly subjects.

Primary objective- To evaluate the effects of ACT-541468 on objective simulated driving performance, i.e., the standard deviation of the lateral position (SDLP), after single- and multiple dose administrations (i.e., on Day 1 and Day 4) in the…

A Randomized, Double-Blind, Vehicle-Controlled, Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Topically Applied INM-755 Cream in Healthy Volunteers

Part 1Primary ObjectiveTo evaluate the local and systemic safety and tolerability of INM-755 cream following repeated once-daily topical applications for 14 days on healthy skin of healthy volunteersSecondary ObjectiveTo assess the local and…

Brain Activity and Motor Behaviour in Infants

To study the neural basis of i) general movements including the transition to the last phase of general movements, the fidgety movements, en ii) the transition from general movements into goal-directed movements using electromyography (EMG),…

Feasibility and Reliability of the Muscle Sound® Technique in a Morbidly Obesity Population

Evaluation of the feasibility and reproducibility of Muscle Sound® in a morbid obese population.

The effects of a nutritional supplement on sleep efficiency, sleep duration and stress, and the effect of audio intervention on deep sleep, in apparently healthy adults with sleep disturbances: a randomized controlled cross-over study

The primary objective is to increase sleep quality, and to assess the effect of audio intervention (SmartSleep; Philips Respironics, Murrysville, PA) on deep sleep. Secondary objectives are to improve sleep efficiency, sleep duration, and to reduce…

Hepatitis C virus transmission dynamics among MSM in Amsterdam: the MSM Observational Study of Acute Infection with hepatitis C.

Objective: - describe and monitor the molecular epidemiology of HCV in MSM in Amsterdam- determine HCV transmission networks in MSM- determine the factors associated with HCV transmission networks- determine role of HIV positive MSM who acquire…

The application of induced pluripotent stem cells to predict return of the same kidney disease after transplantation.

Development of a predictive test for r-FSGS at the individual level of a patient and kidney donor with FSGS.

An Open Label, Single Arm Study to Evaluate the Efficacy and Safety of REGN3918 in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Are Complement Inhibitor Naive or Have Not Recently Received Complement Inhibitor Therapy

The primary objective of the study is to demonstrate a reduction in intravascular hemolysis by REGN3918 over 26 weeks of treatment in patientswith active PNH who are treatment-naive to complement inhibitor therapy or have not recently received…

ECG Belt for CRT Response

The purpose is to compare ECG Belt Research System managed cardiac resynchronization therapy (CRT) patients and a control CRT group with respect to left ventricular (LV) remodeling..

Diagnostic image quality in intra-oral radiography, comparison of hand held and wall mounted X-ray devices; A non-inferiority study with the Nomad Pro hand held X-ray device.

To test if diagnostic quality of radiography with portable devices is non-inferior to that of radiography with wall mounted devices.

A phase 1, 4-period, crossover, open-label study in healthy volunteers to assess the effect of different types of food on a single-dose of JNJ-64417184 administered as tablets.

The purpose of this study is to investigate how quickly and to what extent JNJ-64417184 is absorbed, distributed, metabolized and eliminated from the body. The pharmacokinetics of JNJ-64417184 when it is administered in the morning following the…

Optimizing timing of glucocorticoid treatment in children with congenital adrenal hyperplasia

To study the effects of 2 standard treatment timing strategies for glucocorticoid dosage on androgen concentration in CAH children: a. highest dosage in the morning, b. highest dosage in the evening.

Validating the Positioning Protocol for Whole Leg Radiography

Primary Objective: Test-retest reliability of the measured HKA when patients are positioned following our specific positioning protocol.The main study parameter will be measured using the method as in the current practice. This is a manual method,…

An open-label, mass balance study to investigate the absorption, metabolism and excretion of [14C]-EYP001a after a single oral dose to healthy male subjects

Primary objectives:To determine the ratio of parent drug to metabolites in the circulation following administration of a single oral dose of 400 mg [14C]-EYP001a containing 100 µCi radioactivity.Profiling of EYP001a metabolites in blood, urine and…

A Phase 2 Study of ABBV-3067 Alone and in Combination with ABBV-2222 in Cystic Fibrosis Subjects
Who Are Homozygous for the F508del Mutation

In Part 1 of the study, a fixed dose of ABBV-3067 (potentiator) will be co-administered with ABBV-2222 (corrector) in a dose range-finding manner to enable a dose selection for ABBV-2222 for Part 2 and future combination studies. In addition, ABBV-…

Needle based CLE -EBUS guided- for diagnosis and staging of lung cancer

To assess the feasibility and safety of bronchoscopic/endosonography guided needle based confocal laser endomicroscopy patients with suspected or proven lung tumor and/or mediastinal/hilar lymph node metastases

Track and treat in NSCLC (TATIN) - ctDNA guided treatment of early resistance to targeted treatment in patients with EGFR positive NSCLC

Primary objectives• To identify the percentage of patients in which a drug resistant clone can be detected with ctDNA before the emergence of radiological progression.• To determine the success rate of crizotinib and osimertinib combination…

Analysis of cervical motion during flexion and extension cinematographic recordings in asymptomatic elderly.

Investigate if the normal sequence of segmental contributions in the lower cervical spine during the second half of extension (C4-C5 followed by C5-C6, and then C6-C7) is also present in asymptomatic participants between 55 and 70 years of age by…

MRI in the fast lane: MR-STAT

To assess image quality of MR-STAT-generated synthetic image data sets in patients with neurological diseases (primary objective), and compare image quality of these synthetic images with those acquired individually according to standard clinical…