2920 results
This study results in new insights into the sexual health of young people aged 16 to 25 years living in residential youth care. These insights can be used to improve interventions regarding sexual health that are used by professionals who work with…
Primary objectiveTo investigate the efficacy of low dose colchicine (0.5mg/day) plus usual care (antiplatelet, lipid-lowering, antihypertensive treatment, and appropriate lifestyle advice) compared with usual care alone to prevent non-fatal…
The primary objective is to investigate the differences in mentalizing abilities between outpatients with chronic pain and a control group, consisting of outpatients with painful acute injuries or painful somatically explained conditions. The…
This extension study aims to collect long-term data on safety and efficacy in a subject population treated for ROP with aflibercept and/or laser, and to contribute to the clarification of potential effects.
The purpose of the study is to determine the safety and assess the efficacy of the combination of radium-223 dichloride and pembrolizumab in participants with stage IV NSCLC with bone metastases who are either treatment naïve or have progressed on…
The purpose of this study is to assess short-term and the long-term safety and efficacy of oral ZPL389 (30 mg once daily (o.d.) and 50 mg o.d.) when used concomitantly or intermittently with topical corticosteroid (TCS) and/or topical calcineurin…
The objective of this study is to evaluate the efficacy and safety of upadacitinib versus dupilumab for the treatment of adult subjects with moderate to severe atopic dermatitis who are candidates for systemic therapy.
The primary objective is:• To evaluate the anti-tumor activity of bempegaldesleukin (NKTR-214) in combination with nivolumab by assessing the objective response rate (ORR) by Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST 1.1) per…
Primary: Is OIT with standard food products safe to perform in children aged 9 to 24 months with a proven food allergy for hen's egg, peanut, cow's milk, cashewnut, hazelnut, walnut and/or one of the more rare allergens (as soy, pits and…
*Premature infants and maternal pertussis immunization. Is second trimester vaccination beneficial?*
Our primary objective is to evaluate non-inferiority of anti-Pertussis Toxin (PT) IgG in term infants at 2m of age born of mothers having received a pertussis vaccine between 20-24w Gestational Age (GA) compared to a reference anti-PT IgG at 2m of…
To evaluate the efficacy and safety of brolucizumab used in a Treat-to-Control (TtC) regimen for the treatment of patients with neovascular age-related macular degeneration (nAMD) with the objective to evaluate the potential to reduce treatment…
The objective of the study is to confirm the long-term safety of the Tendril STS and Isoflex leads, implanted with the Assurity MRI* or Endurity MRI* pacemakers, in patients undergoing clinically indicated 3T MRI scans.
Primary objective: To investigate the prevalence of bruxism and TMD in PD patients through objective measurements and to identify factors associated with a higher risk of developing these symptoms.Secondary objectives: - To investigate the salivary…
In this mixed methods study, the main goals are to determine the effect of solution-focused brief therapy (SFBT) on quality of life (quantitative study) and to describe the influence of SFBT on the experiences, emotions and behaviors of the…
The objective of the present study is to evaluate the safety of Womed Leaf after hysteroscopic myomectomy and its potential efficacy in preventing IUA at second look hysteroscopy.
Primary Objectives: - Is IBA non-inferior to CBT in treating patients with OCD?Secondary Objectives:-* Does treatment modality predict pre- to posttreatment changes in neural networks, and is this related to symptom reduction and changes in…
- To evaluate effects of levetiracetam 2000 mg on single and paired pulse TMS-EMG and TMS-EEG in patients with epilepsy treated with mono-therapy levetiracetam, when compared to placebo (levetiracetam trough concentrations). - To evaluatethe effects…
The objective of this study is to evaluate the effect of cabozantinib compared with placebo on PFS and ORR in subjects with RAI-refractory DTC who have progressed after prior VEGFR-targeted therapy.
Primary objective:Determine the short- and long-term safety and tolerability of single and multiple doses of NI006 in subjects with ATTR-CM by evaluating adverse events (AE) and serious adverse events (SAE) and changes in laboratory parameters (…
To investigate neural response patterns to visually and orally presented palatable (high vs low caloric) and unpalatable (high vs low caloric) foods in AN patients and matched healthy controls (HC). This will be investigated through 1 study with 2…