2276 results
The main objective of the study is to investigate the effect of inclusion in the LLA on E33 notifications. Secondary objectives include investigating the effect of inclusion in the LLA on criminal behaviour (arrests, recidivism and risk of…
The objective of this CPS is to establish the clinical performance of F1CDx as a companion diagnostic (CDx) for AZD0022 in patients with NSCLC, CRC, or PDAC with a KRASG12D mutation. This CPSP will be executed in combination with the clinical trial…
The main (primary) objective is to study the influence of sex on the pharmacokinetics (PK) of metoprolol in patients after CABG with heart valve surgery and patients with a STEMI/NSTEMI who are prescribed a standard dosage of metoprolol as part of…
Primary Objective: To determine how exposure to +5Gz forces affects small airway function when breathing ambient air (21% oxygen) and oxygen enriched air (60% oxygen) , without the breathing component of the AGSMSecondary Objective: To explore the…
To compare L-MILP with R-MILP for benign and pre-malignant lesions of the pancreas in high-volume centers, regarding:1. Peri- and postoperative outcomes in terms of COMPOS-panc left score, for non-inferiority2. Total hospital-related costs, for…
The primary objective of this study is to assess the safety and performance of the ABLE Daily to perform ambulatory functions in home and community settings for people with spinal cord injury.The secondary objectives are to assess the impact of the…
Primary objective: To assess the feasibility of donor screening, collection, production and storage of sufficient CB-RBC products to potentially meet the transfusion need in extremely preterm neonates.
1, Quantify and compare vascular and structural parameters obtained from AO-FIO, OCTA, OCT, and CFP in both healthy controls and glaucoma patients; 2, Investigate the correlation between these parameters and assess the additional value of vascular…
The overall aim of the Ageinglines cohort study is to better understand the biological ageing process and its association with the onset (pre)frailty and well-being in later life and to identify targets for delaying the biological ageing process…
to determine if freedom of AF may be improved by delivering more, and targeted PFA applications while avoiding side-effects of higher PFA dosing.
The aim of this study is to compare the efficacy and safety of preoperatively placed Pericapsular Nerve Group block (PENG), Fascia-Iliaca Compartment Block (FICB) and Femoral Nerve Block (FNB) for patients with hip fractures in the ED.
To assess the adherence to the intervention regarding successfully followed exercise sessions, adverse events related to the intervention and experiences of intervention supervisors and participants. Secondly, we will evaluate intervention effects…
Primary objective:What is the incidence of an unsafe swallow situation (PAS score >= 6) after decannulation in ICU patients who had a safe swallow situation with a tracheal cannula prior to decannulation (PAS score < 6)?Secondary…
Primary Objective: Assess which digital health metrics are relevant to monitor for patients with (or highly suspected of having) obstructive sleep apnea before and after diagnosis, and during titration of treatment with continuous positive airway…
The overall aim of this study is to identify and describe distinct recovery trajectories with the innovative digital resilience assessment tool (Orion) in older oncology patients and patients with stage IV lung cancer during systemic therapy.
This study aims to evaluate A-mode ultrasound for assessing JVPW characteristics as a non-invasive tool to discriminate between healthy subjects and those with pulmonary arterial hypertension patients, and to assess if JVPW changes relate to changes…
The primary objective is to evaluate the feasibility of ICG-enhanced near-infrared qFME to determine tumour demarcation and tumour depth in upper GI tumours (e.g. HGD or superficial oesophageal and/or gastric adenocarcinoma (T1)) during ESD.
The REPLACE study aims to determine whether not changing the catheter (catheter retained) for catheter-associated urinary tract infections (CAUTI)affects the recurrence-risk of CAUTI.
To explore whether vigorous endurance exercise (i.e., running a marathon) alters the magnitude of cardiac damage following myocardial ischemia-reperfusion injury in amateur athletes through using an ex vivo rat heart model of myocardial infarction.
Primary objective: - To study the diagnostic accuracy of PCCT (± CT-derived fractional flow reserve [FFRct]) as compared to the reference standard ICA (± FFRinv) in the NSTE-ACS population referred to the UMCG. Secondary objectives: - To study the…