24 results
The primary objective of this pilot trial is to evaluate if adding mitoPO2 monitoring to standard anaesthetic management enables tissue oxygenation optimisation.
The main objective of this longitudinal study is to gain insight into the neurodevelopmental trajectories following neonatal critical illness, from the perinatal period to school-age compared to healthy controls. This insight may lead to the…
The specific trial aim is to establish whether the use of a high, dynamic 8-12 cmH2O PEEP level strategy to support the lung during stabilisation at birth, compared with a static 5-6 cmH2O PEEP level strategy, increases the rate of survival without…
To compare the effect of two target ranges (91%-95% and 92%-96%) while on automated oxygen control on the time spent under the target range in preterm infants.
PrimaryTo characterise the single and multiple dose to steady state pharmacokinetics of IV zanamivirin hospitalised neonates and infants under 6 months of age with influenza infection.SecondaryTo evaluate the safety and tolerability of IV zanamivir…
Evaluate the safety and feasibility of providing automated tactile stimulation in response to apnea, bradycardia and/or desaturation using the BreatheBuddy.
To evaluate the performance of a *genotype first approach* (WES-based panel analysis) in diagnostics of genetic predisposition in children with cancer or neoplasms, compared to the current *phenotype first approach* (standard of care). In particular…
Patients will be included in 3 prospective cohorts, cohort A, B, C and 1 retrospective cohort, cohort 0. Cohort A: The primary objective of cohort A is to show that by implementing a standard infrastructure all newly diagnosed girls with cancer (or…
The primary objective of this study is to determine the relation of delta PO2 (PaO2-tcPO2) and delta PCO2 (tcPCO2-cPCO2) levels to sepsis. The secondary aims are to determine the factors that influence delta PO2 and delta PCO2 and to determine the…
To study the most relevant outcome measures and a cost-effectiveness analysis of laparoscopic PIRS technique compared to open hernia repair in infants aged 6 months to 16 years of age with a primary unilateral inguinal hernia
The primary objective is to determine the difference in median red blood cell velocity (RBV) measured within a time interval of half an hour with dynamic light scattering technology between neonates with and without neonatal late-onset sepsis.
This study has been transitioned to CTIS with ID 2024-518498-32-01 check the CTIS register for the current data. The project*s overarching aim is to diminish respiratory disease burden in moderate-late preterm born infants in their first year of…
To investigate the effect of FCR during hospital stay, accompanied by FICare, on parental stress at discharge in parents of preterm (born before 37 weeks of gestational age) or ill (for instance with sepsis or small for gestational age) infants…
The main objective is to study the effect of the nutritional intervention versus the control product on white matter development (as assessed using tract based spatial statistics of fractional anisotropy) using a DTI scan at the corrected age of…
Our main question is: How does GDM brain immaturity affect skills that are critical for later language development? To answer this question, we will assess two skills in GDM infants and compare them to term controls in two independent (separate)…
This study has been transitioned to CTIS with ID 2024-515625-29-00 check the CTIS register for the current data. The main objective of our trial is to investigate if doxapram is safe and effective in reducing the composite outcome of death and…
Primary objectiveTo establish whether saliva samples could be used as an alternative for blood samples in the therapeutic drug monitoring for amikacin and flucloxacillin. To meet this objective, a PK mod-el will be developed for amikacin and…
Primary objective: To obtain a detailed immunological profile of children presenting to Dutch hospitals with acute SARS-CoV-2 infection or with a SARS-CoV-2 related post-infectious inflammatory syndrome. Secondary objectives: (1) To correlate the…
Our proposal builds on 12 years of sustained EU funding, a consortium covering 11 European countries and 27partners (with non-EU sites in African and two Asian populations to provide a global perspective) and our cuttingedge new research, which has…
The aim of this study is to visualize the position and movement of the vocal cords duringnon-invasive respiratory support of preterm infants after birth.