56 results
Determination of the (cost)effectiveness of the replacement of the expensive, risky and time-consuming food challenge test bythe Basophil Activation Test (BAT) for the diagnosis of an IgE-mediated cow*s milk allergy in children.
Objective: This protocol describes a framework that will be used to create different studies. The general primary and secondary objectives of this protocol are stated below:Primary objective: Investigate the effect of surgery on the position and…
Primary objective: - To develop an automatic segmentation algorithm using artificial intelligence for real-time intra-operative vessel segmentationSecondary objectives: - Post-operative evaluating the accuracy of…
The aim of our study is to study the safety of continued DOAC use during ICA or CAG in elective procedures, by comparing the risk of in-hospital and 30-day bleeding complications between continued and interrupted DOAC use.
To understand the mechanism of action of OA for the treatment of de novo, severely calcified coronary lesions prior to stent placement using optical coherence tomography (OCT) and to assess stent expansion, based on OCT derived minimal stent area (…
The primary objective is to demonstrate efficacy of an extended remote monitoring intervention, including a TM app, HF nurse guided home care and multidisciplinary network collaboration using the Virtual Ward platform, on top of standard HF care…
To evaluate the safety, feasibility and efficacy of an 8-week remotely supervised home-based maintenance exercise training program following pulmonary rehabilitation in patients with COPD.
To investigate the effects of ICIs (anti-CTLA4, anti-PD1, combination anti-CTLA4/PD1) on vascular inflammation (PET-CT) in stage III melanoma patients. We hypothesize that the increase in vascular inflammation will be greater in the exposure group…
1. To study the possibility to detect gynaecological malignancies and endometriosis in vaginal self-swabs, Pap smears and blood of women with gynaecological cancer or endometriosis, using MeD-seq and MeD-scan assays, in order to develop…
Evaluation of the effect of different treatment thresholds in a clinical pathway for children with acute asthma who are treated with supplemental oxygen
To evaluate whether we can determine the health status of the joint by measuring biomarker levels using a newly developed assay by the University of Twente based on the multiplex measurement of a panel of relevant biomarkers using Surface Plasmon…
This project aims to explore the efficacy and safety of radiotherapy for asymptomatic pNET using delivery of radiotherapy by MR-linac in Multiple Endocrine Neoplasia 1 (MEN1) patients.
The primary objective of this clinical Research is: • The objective of the study is to investigate concept and feasibility of view automation for SHD interventions. The study will explore the contribution of (semi) automatic views based procedural…
The primary objective of this study is to evaluate the feasibility and diagnostic accuracy of pre-operative MRI scanning using SPIO compared to lymphoscintigraphy (LS) and single-photon emission computed tomography/computed tomography (SPECT/CT)…
We will combine four 7 Tesla MRI markers in extremely preterm infants (MRSI; SWI; PC-MRI; ihMT) to assess (1) if they can predict outcome until 2 years of age; (2) if they are of added value to 3 Tesla prematurity (Kidokoro et al., 2013) and (3) if…
Primary Objective: Investigate if a tailored diuretic algorithm based on Ur-Na has a positive effect on a composite endpoint of mortality, HF events (HFE) and a change in quality of life (QoL) (assessed with the Kansas city…
The aim of the THRIVE study is to examine two objectives: 1. What are the mechanisms through which friendships aid resilience?a. Does friendship support relate to reduced neural stress responses in young adults with CA?b. Does friendship…
The primary objective of this study is to investigate if the use of Heli-FX EndoAnchors in conjunction with placement of aortic stent grafts under instructions foruse (IFU) conditions in aneurysms with a wide neck is superior to treatment with…
This traditional feasibility study intends to inform a future pivotal trial in the following two ways. Firstly, it aims to evaluate the potential of neural health metrics triggered by FMS, to predict the implant recipient*s auditory performance -…
The primary objective of this study is to establish molecular profiles in lower rectal biopsies as close to the internal fistula orifice tissue and fistula scrapings based on single cell RNA sequencing, cellular protein expression by CyTOF and…