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The accuracy of unsupervised inspiratory capacity measurements performed by COPD patients

Primary ObjectiveTo assess the accuracy of inspiratory capacity measurements performed by COPD patients at rest in a unsupervised home setting compared to a supervised setting.Secondary objectives - To assess the accuracy of inspiratory capacity…

A phase II, randomised, double blind, placebo-controlled study of the pharmacokinetics, pharmacodynamic effects, and safety, of oral FT011 in participants with diffuse systemic sclerosis

Primary objective: To assess the PK of oral FT011 in participants with diffuse SSc.Secondary objectives: • To assess the safety and tolerability of oral FT011 compared to placebo in participants with diffuse SSc.• To evaluate the short-term efficacy…

A Randomized, Double-Blind, Placebo-Controlled, Multiple Rising Oral Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of TAK-994 in Patients With Narcolepsy With or Without Cataplexy (Narcolepsy Type 1 or Narcolepsy Type 2)

PART A and PART DTo assess the safety and tolerability of TAK-994 following multiple oral doses in subjects with narcolepsy with or without cataplexy (NT1 or NT2).PART B and PART C To assess the efficacy of TAK-994 on reducing excessive daytime…

A Phase 3, Randomized, Open-Label, Parallel-Group Study to Compare the Pharmacodynamics, Pharmacokinetics, Efficacy, Safety, Tolerability, and Immunogenicity of Multiple Subcutaneous Injections of Efgartigimod PH20 SC with Multiple Intravenous Infusions of Efgartigimod in Patients with Generalized Myasthenia Gravis (ADAPT)

Rationale:The aim of this study is to investigate the pharmacodynamics (PD), pharmacokinetics (PK), safety, tolerability, immunogenicity, and clinical efficacy of efgartigimod coformulated with recombinant human hyaluronidase PH20 (rHuPH20)…

Personal protein digestion variability

Primary Objective: To quantify the variation in post-prandial plasma AA profiles between (and within) individuals after consumption of a poorly digestible plant protein source (lucerne). Secondary Objective: To compare the variation in postprandial…

Defining type 2 asthma phenotypes based on clinical, biological and functional parameters using cluster analysis.

The main objective is to investigate the heterogeneity of type 2 asthma by identifying phenotypes by means of cluster analysis. Secondary, the clinical interpretation of these clusters is investigated.

In vitro potency of clinically used antiplatelet drugs in patients with Metabolic dysfunction Associated Fatty Liver Disease

To compare the in vitro potency of commonly used antiplatelet drugs in the blood of patients with various stages of fibrosis due to MAFLD, compared to that in blood of individuals without underlying liver disease.

Management of psoriasis and risk and severity of COVID-19 infection in systemic, biologic and topical treatment for psoriasis during the COVID-19 pandemic: an epidemiological cohort study

Evaluate the point-prevalence, relative risk and severity of COVID-19 infections in psoriasis patients treated with immunosuppressive biologicals or conventional systemic immunosuppressive therapies as compared to topical treatments. Furthermore, we…

Medical hypnosis with VR glasses to reduce pain and anxiety during needle related procedures in children

The aim of the study is to measure the effect on pain during needle-related procedures using VR hypnosis glasses versus hypnosis by a health care professional. Secondarily, anxiety, blood pressure, heart rate and patient satisfaction are measured.

A phase 3 extension trial of DELTA 1 and DELTA 2 to evaluate the long-term safety of a twice-daily treatment with delgocitinib cream 20 mg/g as needed for up to 36 weeks in adult subjects with chronic hand eczema (DELTA 3)

Primary objective:To evaluate the long-term safety of an as-needed treatment with twice-daily applications of delgocitinib cream 20 mg/g.Secondary objective:To evaluate the long-term efficacy of an as-needed treatment with twice-daily applications…

Anaesthetic management guided by cellular oxygen metabolism measurements

The primary objective of this pilot trial is to evaluate if adding mitoPO2 monitoring to standard anaesthetic management enables tissue oxygenation optimisation.

A Randomized, Drug-Drug Interaction Study to Assess the Safety and Pharmacokinetics of VNRX­7145 and Ceftibuten (VNRX­5024) in Healthy Adult Volunteers

In this study we will investigate how safe the new compound VNRX-7145 and the combination of 2 study compounds, the new compound VNRX­7145 and the approved compound ceftibuten, are and how well they are tolerated when they are used by healthy…

Explorative study on unobtrusive sleep monitoring technologies: prolonged in-home measuring in the sleep-disordered population (PRISM study)

The aim of this study is to research if the same measures of macrostructural sleep parameters and abnormal sleep behavior can be obtained with home monitoring technologies as with a clinical PSG.

A randomized, double-blind, placebo-controlled, multicenter study of ensovibep (MP0420) in ambulatory adult patients with symptomatic COVID-19

The study has the purpose and rationale to establish the antiviral efficacy of ensovibep against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in humans, identify the optimal dose, and demonstrate its clinical value for treating COVID…

The impact of the dietary protein matrix on post-prandial plasma amino acid responses in vivo in healthy young females

To assess the impact of protein in a solid (bar) and liquid (drink) form on post-prandial amino acid responses in vivo in healthy young women.

Rescue Alkaline Phosphatase In Defense against all cause Acute Kidney Injury

To study the potential renoprotective effects of supplementation of alkaline phosphatase in hospitalized patients with AKI

Supporting early recognition of clinical deterioration for Mobile Vital signs monitoring of high-risk surgical patients

Primary objective: 1. To develop and evaluate a model for prediction of deterioration necessitating escalation of care, based on continuous vital signs recordings, self-reported patient symptoms, nurse observations, clinical measurements, and…

Effect of Bacillus Calmette-Guérin vaccination on the immunogenicity of the mRNA BNT162b2 COVID-19 vaccine in health care workers

To determine the impact of prior BCG vaccination on the duration of immunogenicity of the BioNTech/Pfizer mRNA COVID*19 vaccine.

A natural history study on infantile facioscapulohumeral muscular dystrophy: five-year follow-up

The primary objective of this study is to further discribe the natural course and clinical characteristic of infantile FSHD.The secondary objectives are: - To identify (epi)genetic and environmental disease modifying factors that contribute to…

The influence of different anatomical positions on the location of the S-ICD pulse generator

Primary Objective:* The primary objective of this study is to determine the influence of different anatomical positions on step 2 of the PRAETORIAN score.Secondary Objective(s):* The influence of the different anatomical positions on the total…