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A Phase 2a open label, non-comparative, single dose escalation study to evaluate the dynamics of viral clearance, pharmacokinetics and tolerability of ensovibep in patients with symptomatic COVID-19 disease

Primary* To characterize the dynamics of viral clearance (incl. viral cultures, qPCR, antigen clearance) following ensovibep administration * To characterize the serum pharmacokinetics of two single i.v. flat dose levels of ensovibep in patients…

Enhancing the perception of pain using virtual reality: a pilot study

To assess the effect of Virtual Reality mediated visual and auditory lowering of electrical pain detection and tolerance thresholds

Evaluating the effect of zolpidem and suvorexant in healthy elderly volunteers on walking (adapt)ability.

* To assess effect of zolpidem compared to placebo on walking (adapt)ability in healthy elderly as measured by the Interactive Walkway. * To assess effect of suvorexant compared to placebo on walking (adapt)ability in healthy elderly as measured by…

Early clinical feasibility study of a new voice prosthesis: the Provox Vega HP

The objectiveof this study is to evaluate the short term clinical applicability of the Provox Vega HP and to investigate its potential limitations and benefits. As a result of the evaluations, the design could be adapted to arrive at the optimal…

A Randomized, Double-Blind, Placebo-Controlled, Phase 1, Single and Multiple Ascending Dose Study to Assess the Safety, Pharmacokinetics, Pharmacodynamics, and Food Effect of THB001 in Healthy Subjects

Part 1 - Single Ascending Dose (SAD):Primary objective:• To evaluate the safety and tolerability of single oral doses of THB001 in healthy subjects.Secondary objectives:• To characterize the plasma pharmacokinetic (PK) profile of single oral doses…

Piezo-electric versus optical versus open wire pressure guidewires for FFR measurements: comparison of two commercially available pressure wires

- To compare the pressure signals measured by the different available pressure guidewires, specifically the FFR value- To assess the occurrence of hydrostatic errors when using sensor-tipped wires- To assess the occurrence of drift between the…

The feasibility of home monitoring for patients undergoing outpatient surgery for elective hip or knee replacement

The purpose of this study is to evaluate the feasibility of postoperative home monitoring for patients undergoing outpatient knee- or hip arthroplasty; discharged on the same day as surgery; less than 12-hour hospital stay.We hypothesise that a…

Development, dIagnostic and prevention of gender-related Somatic and mental COmorbitiEs in iRritable bowel syndrome In Europe

Primary Objective: The overarching goal of the multicentre trial is to characterize the overlap between mental and non-mental comorbid conditions of IBS. In IBS and patient control groups we will characterize depression, anxiety, fibromyalgia and…

4D flow hemodynamics in the coronary arteries in adults after arterial switch operation for transpostion of the great arteries

The main objective in this explorative study is to perform 4D flow MRI measurement in the reimplanted coronary arteries in arterial switch patients to give insight into the coronary blood flow patterns and investigate the impact of anatomical high…

Transcranial ultrasonic stimulation of the primary motor cortex

Our primary objective is to replicate two experiments conducted by Fomenko and colleagues (2020), the first investigating whether TUS over M1 decreases excitability, and the second investigating whether varying TUS sonication duration significantly…

The impact of jumping exercise and collagen supplementation on bone turnover markers in healthy males

The main objective of the current project is to assess the effect of jumping exercise combined with collagen supplementation on bone turnover. This will be investigated by means of two sub-studies.Sub-study 1a: To examine the effect of collagen…

Ultrafast ultrasonic COMpound Push wave imAging and Strain eStimation (Ultra-COMPASS) for individual plaque stratification in the carotid arteries

Investigate whether it is possible to detect plaque stabilization, determined by plaque stiffness, after a stroke or TIA with Ultra-COMPASS ultrasound measurements.

A double-blind, placebo-controlled, randomized dose-ranging trial to investigate efficacy and safety of intravenous MIJ821 infusion in addition to comprehensive standard of care on the rapid reduction of symptoms of Major Depressive Disorder in subjects who have suicidal ideation with intent

The main purpose of the study is to support dose selection for future Phase 3 clinical trials by evaluating the efficacy and safety of four MIJ821 doses (0.0048, 0.016, 0.048 and 0.16 mg/kg) administered every other week by intravenous infusion on…

Establishing the safety, tolerability and immunogenicity of intradermal delivery of mRNA SARS-CoV-2 vaccine in healthy adults

Primary objectives:- to describe tolerability, safety and immunogenicity in healthy adults of the intradermal delivery of one or two fractional doses of 10 µg and 20 µg mRNA-1273 LPN vaccine (Moderna).- to compare the immunogenicity in healthy…

Bone blood perfusion of the patella with non-invasive spectroscopy in patients with patellofemoral pain

Investigate differences in bone blood flow of the patella in patients with PFP compared to healthy controls. Before studying differences reliability of the proposed protocols has to be established.

A randomised, double-blind, placebo-controlled crossover study to investigate the effect of buprenorphine on fentanyl induced effects on nociceptive thresholds and CNS functioning in opioid tolerant patients.

Primary objectives- To evaluate the effects of buprenorphine on fentanyl induced analgesia using the PainCart test battery in OT patients, when compared to placebo.Secondary objectives- To evaluate the effects of buprenorphine on fentanyl induced…

Articulation and coordination of speech after treatment for oral cancer

To investigate the timing and coordination of speech articulation and its relation to speech disorders of people who have been treated for oral cancer with a major resec-tion. This information will lead to a better understanding of articulation and…

Clinical assessment of upper extremity performance in individuals with spinal cord injury using the LIFT System to deliver non-invasive electrical spinal stimulation (ARC Therapy)

Safety: To provide confirmatory evidence that use of the LIFT System, inclusive of all components and accessories, is safe.Effectiveness: To provide confirmatory evidence that use of the LIFT System provides an effective treatment for the…

Measuring differences in breathing patterns between asthma patients and healthy subjects during physical exercise and the effect on the level of dyspnoea using respiratory inductance plethysmography

To investigate the breathing patterns of asthma patients during exercise, compare this with the breathing pattern of healthy subjects and investigate whether the breathing pattern influences EID in patients with asthma.

Study of EMF Neutrophil Activation effects phase 1

To show that this EMF exposure activates neutrophils in a group of subjects with diversity in age and gender.