649 results
The aim of this study is to measure eCAPs intraoperatively (and perform electrocochleography [ECochG] in case of any residual hearing) and to estimate cochlear health in these patients by applying insights gained from our guinea pig experiments.
Does isolated cup revision surgery or liner exchange through the anterior approach result in increased functional status and higher patient satisfaction than through the posterolateral approach?
Primary: To evaluate the ability to culture PDEC organoids from pancreatic duct biopsies. Secondary: (i) To evaluate ion transport in PDEC organoids derived from pancreatitis patients. (ii) To evaluate the ability of duodenal organoids to mimic ion…
To assess the impact of SBRT in combination with systemic therapy compared to systemic therapy alone on safety and efficacy in patients with mCRC.
This study has been transitioned to CTIS with ID 2024-517960-45-00 check the CTIS register for the current data. • To assess the relative change in uptake of [18F]F-AraG in tumor lesions upon anti-PD-1 treatment• To assess the relationships between…
Primary Objective: To investigate whether a quantitative MRI protocol can detect the difference between atypical parkinsonism and patients with Parkinson*s disease, in an early phase of the diseases when the clinical diagnosis for either is not yet…
This study has been transitioned to CTIS with ID 2024-516153-52-00 check the CTIS register for the current data. Primary objective: To demonstrate efficacy of emapalumab in the treatment of patients in:• Cohort 1: Macrophage activation syndrome (MAS…
This study has been transitioned to CTIS with ID 2023-505483-11-00 check the CTIS register for the current data. To investigate if early transition to oral treatment after two weeks or longer of IV antibiotic therapy is non-inferior to standard six…
Predict response to FOLFIRINOX treatment in patients with LAPC based on baseline stiffness values derived with MRE.
The primary objective is to develop a disease model predicting clinical meaningful changes based on a combination of results of tests on clinical function, muscle MRI, echocardiography and circulating biomarkers applicable in various stages of…
To determine the technical feasibility of cholangioscopy using the Spyglass DS II system in the pre-operative work-up of resectable EC.
To investigate whether VR-VOICES is more effective than regular treatment for voicehearing in patients with auditory hallucinations.
Primairy objective:Explore the prevalence of the ABI-effect, by mapping the participation level. Secundary objective:Substatiate the occurence of the ABI-effect, by mapping cognitive functions of patients and compare these to healthy controls.…
The Galvani Splenic Neuromodulation System consists of a lead, rechargeable implantable pulse generator, external components and accessories. The system is designed to deliver electrical stimulation to the splenic NVB in patients with moderate to…
The primary aim of this RCT is to evaluate whether the use of oral supplementation of hydrolysed collagen/vitamin C in addition to usual care (education, load management and PTLE) is superior to usual care and placebo on VISA-P score after 24 weeks…
This study has been transitioned to CTIS with ID 2023-503793-20-00 check the CTIS register for the current data. The main purpose of this study is to learn whether asundexian works better than placebo at reducing ischemic strokes in participants who…
The aim of the current project is to test the clinical and cost-effectiveness of GST for patients with an ED (i.e., anorexia nervosa, bulimia nervosa, other specified), that are not likely to benefit from CBT-E. The study will focus on those…
This study has been transitioned to CTIS with ID 2024-518855-43-00 check the CTIS register for the current data. Primary objective: To evaluate the effect of SGLT2 inhibition with dapagliflozin 10 mg on serum magnesium in diabetic and non-diabetic…
Primary objectives: To determine the effects of combined isocaloric TRE and meal timing on insulin sensitivity.Secondary objectives: To determine the effects of combined isocaloric time-restricted eating and meal timing on hepatic fat content, de…
This study has been transitioned to CTIS with ID 2023-506824-96-00 check the CTIS register for the current data. • safety and tolerability from baseline to week 64 in participants with hATTR or wtATTR cardiomyopathyPrimary • To compare the effect of…