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The UPDATE trial (Uvb Phototherapy in Dermatology for ATopic Eczema): A multicenter randomized controlled trial of narrowband UVB versus optimized topical therapy in patients with atopic eczema.

Comparing the effectiveness and cost-effectiveness of narrowband ultraviolet B with optimal topical therapy (NB-UVB+OTT) versus OTT at 3 months in adult patients with atopic eczema (AE).

EMDR for Fear of Cancer Recurrence in Patients with Familial Melanoma. A waiting list control trial

Primary Objective: The aim of the proposed study is to investigate whether EMDR is effective in lowering fear of cancer recurrence in patients with familial Melanoma. Secondary Objective(s): effectiveness of EMDR and quality of life at 3 months…

Phase IIIb, open-label, single-arm, multi-center study to evaluate the safety, tolerability and efficacy of OAV101 administered intrathecally (1.2 x 1014 vector genomes) to participants 2 < 18 years of age with spinal muscular atrophy (SMA) who have discontinued treatment with nusinersen (Spinraza®) or risdiplam (Evrysdi®)

The purpose of this study is to characterize the safety and tolerability of OAV101 IT in participants who have discontinued treatment with nusinersen (Spinraza®) or risdiplam (Evrysdi®). The data from this study will expand on the data generated…

National PROspective infrastructure for Renal Cell Carcinoma

To set up a prospective, nationwide infrastructure that identifies and follows patients diagnosed with RCC and mRCC over time. This infrastructure will:• evaluate oncological and functional outcomes for patients diagnosed with RCC;• evaluate the…

A FEASIBILITY STUDY OF SGM-101, A FLUOROCHROME-LABELED ANTI-CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY FOR THE INTRAOPERATIVE DETECTION OF COLORECTAL BRAIN METASTASES

This study has been transitioned to CTIS with ID 2024-510767-30-00 check the CTIS register for the current data. 1. To determine the feasibility of SGM-101 for intraoperative imaging of colorectal brain metastases - Concordance between fluorescent…

A First in Human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of IBC-Ab002 in Persons with Early Alzheimer's Disease

This study has been transitioned to CTIS with ID 2024-511770-76-00 check the CTIS register for the current data. Primary* To assess safety and tolerability of IBC-Ab002 following single and multiple ascending doses in persons with early ADSecondary…

Wrist implant safety evaluation (WISE) study

To investigate the safety and performance of a patient-matched injection molded Bionate ® II 80A radiocarpal interposition arthroplasty implant in adult patients with posttraumatic radiocarpal osteoarthritis.

Phase II, Multi-Center, Randomized, Blinded Study Evaluating the Efficacy, Safety and Tolerability of a Single Intratympanic Dose of AC102 Compared to Oral Steroids for the Treatment of Idiopathic Sudden Sensorineural Hearing Loss.

This study has been transitioned to CTIS with ID 2024-513658-31-00 check the CTIS register for the current data. The primary objective of this study is to assess the efficacy of a single intratympanic injection of AC102 compared to oral steroids in…

DESCARTES trial: De-ESCAlating RadioTherapy in patients with pathologic complete rESponse to neoadjuvant systemic therapy.

Primary aim: to assess whether local recurrence is acceptable when radiotherapy is omitted after breast conserving surgery in patients treated with NAC who achieve a pathologic complete response.Secondary aim: to assess quality of life and cancer…

The influence of sacral neuromodulation on brain areas involved in the sensation of bladder filling in patients with Overactive Bladder (OAB) using fMRI

2.1 Primary Objectives• To identify brain activation evoked by sensation in response to bladder filling in patients with an implanted sacral neurostimulator as a treatment for overactive bladder (OAB), compared to a baseline in OAB patients without…

Towards optimal management of Marfan Syndrome

The aim is to investigate the value of novel MRI parameters for aortic hemodynamics and aortic motion and pressure waveforms in MFS patients as potential new biomarkers for guiding surgical and medical treatment of MFS, by analysing these parameters…

Validation of CPM#1 compressibility in healthy volunteers in rest and after exercise

The primary objective is - To clinically validate the inter-observer reliability of compressibility measurements with the CPM#1 device during rest in healthy volunteers.

Protein supplementation and exercise training to increase muscle protein synthesis rates in patients with advanced chronic kidney disease

1. To assess whether the skeletal muscle protein fractional synthesis rate as measured by the deuterated water method is different during a 1-week habitual lifestyle period when compared to a 1-week period with resistance-type exercise and protein…

A Phase 1/2 Open-label Study to Investigate the Safety, Efficacy, and Pharmacokinetics of Administration of Subcutaneous Blinatumomab for the Treatment of Adults with Relapsed or Refractory B cell Precursor Acute Lymphoblastic Leukemia (R/R B-ALL)

This study has been transitioned to CTIS with ID 2023-506136-32-00 check the CTIS register for the current data. Primary:Dose Escalation• Evaluate the safety and tolerability of subcutaneous (SC) blinatumomab for treatment of Relapsed or Refractory…

The RENAL LIFECYCLE trial: A Randomized Controlled Clinical Trial to Assess the Effect of Dapagliflozin on Renal and Cardiovascular Outcomes in Patients with Severe Chronic Kidney Disease

This study has been transitioned to CTIS with ID 2023-508389-13-00 check the CTIS register for the current data. To determine whether dapagliflozin is superior to placebo in reducing the incidence of the primary composite endpoint of kidney failure…

A Phase II, Multi-center, Open-Label Study to Assess Safety, Tolerability, Efficacy and Pharmacokinetics of R3R01 in Alport Syndrome Patients with Uncontrolled Proteinuria on ACE/ARB Inhibition and in Patients with Primary Steroid-Resistant Focal Segmental Glomerulosclerosis.

This study has been transitioned to CTIS with ID 2024-512964-73-00 check the CTIS register for the current data. The overall objective is to investigate the safety, tolerability, efficacy and pharmacokinetics of R3R01 administered daily for 3 months…

Safely reduce cystoscopic evaluations for microscopic Hematuria patients (SeARCH Trial).

To assess the clinical impact of implementing a molecular urine test in the diagnostic workup of patients presenting with microscopic hematuria.

Preoperative chest CT-imaging in surgical aortic valve replacement with or without CABG: a randomized controlled trial.

The purpose of this RCT is to improve the outcome of surgical treatment of severe and/or symptomatic aortic valve pathology with or without concomitant coronary artery disease by reducing morbidity (stroke) and change of operative strategy in…

A Randomised, Double-Blind, Placebo-Controlled, Single- and Multiple-, Ascending-Dose Study of the Safety, Tolerability, and Pharmacokinetics and Pharmacodynamics of VRG50635 and Food Effect in Healthy Volunteers (Phase 1a)

Part 1; Single ascending dose (main objective)• To investigate the safety and tolerability of single oral doses of VRG50635 in healthy adult subjectsPart 1; Single ascending dose (secondary objective)• To characterize the plasma and urine…

A randomized, double-blind, double-dummy, parallel-group study, comparing the efficacy and safety of remibrutinib versus teriflunomide in participants with relapsing multiple sclerosis, followed by extended treatment with open-label remibrutinib.

This study has been transitioned to CTIS with ID 2023-509345-12-00 check the CTIS register for the current data. The purpose of the study is to provide efficacy, safety and tolerability data for remibrutinib to support regulatory approval worldwide…