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Evaluation of adhesions formation using conventional third generation endometrial ablation with and without postoperative application of an intrauterine adhesion barrier film

Evaluate the formation of adhesions after third-generation endometrial ablation, with and without the intrauterine adhesion barrier

A randomized, double-blind, phase III study comparing NIS793 in combination with gemcitabine and nab-paclitaxel versus placebo combined with gemcitabine and nab-paclitaxel for first line treatment of metastatic pancreatic ductal adenocarcinoma (mPDAC)

The purpose of this study is to evaluate the efficacy and safety of NIS793 in combination with gemcitabine/nab-paclitaxel versus gemcitabine/nab-paclitaxel and placebo in first-line mPDAC.This study aims to explore whether blockade of Transforming…

Double-blind, placebo-controlled phase 1 trial of nizaracianine administered in three divided doses to healthy volunteers

Primary• To assess the safety and tolerability in healthy volunteers of nizaracianine administered IV in three divided dosesSecondary• To perform pharmacokinetic analyses of blood and urine• To determine if bolus injection of nizaracianine enables…

Individualisation of management with novel upfront therapy enzalutamide in newly diagnosed metastasized prostate cancer using (PSMA)PET/CT imaging

To assess the predictive value of early response measurements on PSMA-PET/CT for therapy success, defined as time to development of castration-resistant prostate cancer (CRPC), in order to personalize treatment choice.

A Phase 1 Study to Assess the Mass Balance, Absolute Bioavailability, and Pharmacokinetics of 14C-ASTX029 in Healthy Volunteers

Primary objectives:To identify and quantify the excretion pathways of oral ASTX029, including the mass balance and the excretions in urine and feces (Period 1).To determine the absolute oral bioavailability (F) of ASTX029 under fasting conditions (…

A Study to Evaluate the Safety, Tolerability, and Effects on NSAID-Induced Small Bowel Pathology of K-196 in Healthy Volunteers.

Primary:1. To characterize the safety and tolerability of multiple oral doses of K-196 alone and in combination with naproxen/omeprazole in healthy subjects.Secondary:1. To assess the effects of K-196 compared to placebo on the proportion of…

Dopaminergic mechanisms of inference for language: a pharmaco-fMRI study

The primary objective of this study is to investigate whether increases in brain dopamine enhance novel meaning inference in language processing, and what cognitive and neural mechanisms underlie this. We will test the hypothesis that dopamine…

Effects of recreational nitrous oxide use on psychomotor functioning related to driving performance

Primary Objective: To answer the question: How long after the use of a typical recreational dose of nitrous oxide (4 liters, 100%, bolus administration via inhalation) is there a measurable negative impact on psychomotor functioning?Secondary…

Study of Females Exposed to Eleclazine

The objective of this study is to follow up with females exposed to eleclazine in prior clinical trials.

Assessment of Patient-reported Symptoms and Endoscopic, Histologic, and Biomarker Outcomes in Patients With Acute Pouchitis Treated with Antibiotics

The primary objective of this study is to evaluate the reliability and responsiveness of patient reported symptoms and endoscopic and histologic items for assessing pouchitis disease activity in patients undergoing SOC antibiotic therapy.A secondary…

Distribution, dosimetry and imaging of [195mPt]cisplatin in cancer patients

Investigate the distribution, dosimetry and image quality of [195mPt]cisplatin in cancer patients

Aronia and Cognitive Fitness: Focus on Brain Insulin-Sensitivity and Vascular Function

The primary objectives are to investigate effects of AME intake on brain vascular function and insulin-sensitivity in cognitive-control brain areas, while we will also evaluate changes in cognitive function (secondary objective).

The Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics (AURORA) Household Plastics Study

Primary Objective: 1) To assess determinants of circulating MNP levels in Dutch females of reproductive age, including the relative contribution of indoor sources, food packaging and preparation methods to MNP and plastic-associated chemical body…

A randomized controlled trial on the visual function after bilateral implantation of two novel Extended Depth-of-Focus intraocular lenses.

The primary objective of this study is to compare the binocular uncorrected intermediate visual acuity (UIVA) at 66 cm under photopic conditions 3 months postoperatively, in a series of patients bilaterally implanted with the Acunex® Vario IOL…

An interventional, non-invasive, monocentric study to evaluate the safety and performance of the wearable ultrasound bladder sensor (SENSA) in adult patients with urinary incontinence problems

Primary objectiveDemonstrate that the SENSA Bladder Sensor can detect the bladder before urination among its adult intended user Secondary objective(s)1) Collect real-life data to evaluate the clinical performance of the SENSA Bladder Sensor, the…

A Phase 1/1b Open-Label, Multicenter, to Investigate the Safety, Tolerability, Pharmacokinetics, and Antitumor Activity of KIN 2787 in Participants with BRAF and/or NRAS Mutation positive Solid Tumors

Part A1(KIN-2787 Monotherapy Escalation):Determine safety and tolerability of PO administration of Kin-2787 including DLT in participants with BRAFmutation-positive advanced or metastatic solid tumors or melanoma harboring NRAS-mutation. Identify…