791 results
The aim of this study is to improve our understanding of clinical, virological, and psychosocial outcomes in patients with MPXVID. To get a better understanding of associated risk factors for MPXV infection, and to measure quality of life and stigma…
The primary objective is to evaluate whether cyclic daytime enteral feeding can decrease the disruption of circadian rhythms in critically ill patients compared to continuous enteral feeding. Secondary objectives are to evaluate the effect of cyclic…
To evaluate the (cost-)effectiveness of SBRT (with active dose-sparing of the surgical site) followed by surgical stabilization with or without decompression within 24 hours for the treatment of symptomatic, unstable metastases of the cervical,…
This study has been transitioned to CTIS with ID 2022-502140-13-00 check the CTIS register for the current data. 1. To compare bleeding risk (i.e. safety) with DAPT compared to standard therapy during the first 30 days following PCI/ACS in patients…
This study has been transitioned to CTIS with ID 2024-516770-29-00 check the CTIS register for the current data. The objective of this study is to evaluate the clinical efficacy, biological effects and safety of anifrolumab treatment in pSS.
The primary objective of this study is to evaluate the incidence of hypoglycemia in adult and pediatric patients with GSD III. The secondary objective of this study is to evaluate the sensitivity of various muscle strength and function measures to…
The aim of this study is to determine whether VR used during lumbar puncture will significantly reduce pain and anxiety perception.
Primary objectiveTo collect data for the continuous development of an algorithm to determine the bladder filling status with the future TENA Bladder Sensor.Secondary objectiveTo document adverse events (AE) and device deficiencies (DD): namely AEs,…
This study aims to achieve 4 goals: (1) to identify the brain network involved in mediating the effects of cueing as an important compensation strategy; (2) to identify differences in brain connectivity patterns elicited by internal versus external…
The primary objective is to increase our understanding of the glucoCEST signal by comparing glucoCEST MRI to [18F]FDG-PET in patients with brain tumours on the hybrid PET/MRI scanner of the Erasmus MC. The secondary objective is to explore the…
The primary objective of this trial is to assess the effects of WHM, involving breathing exercises, mindset (and cold exposure), on health-related quality of life in people with SCI. The secondary objectives are to assess the effects of WHM,…
The purpose of this study is to allow collection of safety and tolerability data in subjects benefitting from treatment with spartalizumab as a single agent or in combination with other study treatments in a pre-defined (Appendix Section 16.1)…
to compare data from nose brush cells and blood cells from CF patients, obtained in the TERRIFIC studie, to the data in healthy controls.
This study has been transitioned to CTIS with ID 2023-506384-34-00 check the CTIS register for the current data. Primary:- To assess the safety and tolerability of MK2140- To evaluate objective response rate (ORR) of MK2140 as assessed by BICR per…
Metabolic effects of ketohexokinase inhibition in individuals with non-alcoholic fatty liver disease
Primary objective: determining the effect of the ketohexokinase inhibitor, PF-06835919, on hepatic insulin sensitivity in individuals with non-alcoholic fatty liver disease.Secondary objective: determining the effect of the ketohexokinase inhibitor…
This study has been transitioned to CTIS with ID 2024-511151-18-00 check the CTIS register for the current data. • Determine a feasible 89Zr-brentuximab-PET imaging schedule, to allow assessment of the biodistribution of 89Zr-brentuximab in tumor…
The primary objective of this study is to investigate the effects of personalized dietary guidance to increase the intake of fibre-rich foods, as recommended in the Dutch dietary guidelines, on cardiometabolic risk profile in individuals who have…
Primary objective: To investigate if the presence of aneurysm wall enhancement predicts aneurysm instability in the long-term. Secondary objective: To investigate if the absence of aneurysm wall enhancement predicts aneurysm stability in the long…
Primary objective:1. To evaluate the negative predictive value (NPV) of [68Ga]Ga-PentixaFor (PTF) PET at interim examination (after 6 ± 2 weeks of induction chemotherapy) for progression-free survival (PFS). Secondary objectives:2. To evaluate the…
This study has been transitioned to CTIS with ID 2023-505057-40-00 check the CTIS register for the current data. This study is looking at how safe the combination of the experimental drugs dostarlimab, belrestotug and GSK6097608 is in patients with…