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Optimizing INITIation of non invasive ventilation in ALS patients

The primary objective of this study is to build a predictive model in which we can identify which (pheno) type of ALS patients has the most benefit from NIV in improving or maintaining quality of life.

Workflow Optimization to Reduce Time to Endovascular Reperfusion for Ultra-fast Stroke Treatment

Primary objective:• To demonstrate that the DTAS triage workflow involving CBCT results in superior patient outcome in ischemic stroke patients with confirmed Large Vessel Occlusion (LVO) as compared to the conventional CT/MR triage workflow.…

Distribution, dosimetry and imaging of [195mPt]cisplatin in cancer patients

Investigate the distribution, dosimetry and image quality of [195mPt]cisplatin in cancer patients

RESET-TRD; a Randomised trial on oral ESketamine compared to Electroconvulsive Therapy for patients with Treatment Resistant Depression

This study has been transitioned to CTIS with ID 2024-517485-42-00 check the CTIS register for the current data. To investigate whether oral esketamine is non-inferior to ECT in achieving treatment response on depression severity in NTRD.

A40 EFL Registry: A Multicenter Prospective Study to Determine the Role of EFL in Patients with Chronic Obstructive Pulmonary Disease (COPD) Receiving Home Mechanical Ventilation
Protocol ID: SRC_HRC_VectorEURegistry_2019_10820

a. To determine what proportion of COPD patients demonstrate EFL during NIV useb. To determine the range of EPAP necessary to overcome EFLc. To determine longitudinal change of EFL with time and interaction with exacerbationd. To describe the…

A phase I/IIa open label study to assess the safety, tolerability, immunogenicity and clinical activity of EI-201 mRNA immunotherapy given intravenously in subjects with recurrent or metastatic HPV16 positive carcinoma

COHORT 1Primary objective: • To assess the safety and tolerability of IV administration of EI 201 as monotherapy in subjects with incurable R/M HPV16+ oropharyngeal and anogenital tumors and to select a starting dose of EI-201 for Cohort 2 Secondary…

Cardiac metabolic profiling in the fed state

The primary aim of this study is to provide insight into cardiac substrate utilization in the fed state.

A Prospective Randomized Multicenter Single Blinded Study to Assess the Safety and Effectiveness of the SELUTION SLR* 014 Drug Eluting Balloon in the Treatment of Below-the-Knee (BTK) Atherosclerotic Disease in Patients with Chronic Limb Threatening Ischemia (CLTI)

To demonstrate superior efficacy and non-inferior safety of the SELUTION SLR 014 DEB compared to PTA (uncoated balloon) in the treatment of peripheral arterial disease (PAD) in the BTK arteries in CLTI patients.

An open-label, non-randomized extension study to evaluate the long-term efficacy, safety and tolerability of iptacopan (LNP023) in subjects with C3 glomerulopathy or idiopathic immune-complex-membranoproliferative glomerulonephritis

This study has been transitioned to CTIS with ID 2023-509343-27-00 check the CTIS register for the current data. Participants enrolling from study CLNP023B12301 or CLNP023B12302• Primary Objective: To evaluate the long-term safety and tolerability…

Longer-term effects of peanut consumption on brain function in older men and women.

The primary objectives are to investigate in older men and women the effect of 16-week peanut consumption on brain vascular function and brain insulin-sensitivity in cognitive-control brain areas, while we will also focus on changes in cognitive…

A PHASE Ia/Ib, OPEN LABEL, MULTICENTER, DOSE-ESCALATION STUDY TO EVALUATE THE SAFETY, PHARMACOKINETICS, AND ACTIVITY OF RO7502175 AS A SINGLE AGENT AND IN COMBINATION WITH ATEZOLIZUMAB IN PATIENTS WITH LOCALLY ADVANCED OR METASTATIC SOLID TUMORS

This study has been transitioned to CTIS with ID 2023-504709-35-00 check the CTIS register for the current data. This is a first-in-human Phase Ia/Ib, open-label, multicenter, dose-escalation study designed to evaluate the safety, tolerability,…

A Phase 3 Randomized Study Comparing Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) followed by Ciltacabtagene Autoleucel versus Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) followed by Autologous Stem Cell Transplant (ASCT) in Participants with Newly Diagnosed Multiple Myeloma who are Transplant Eligible

This study has been transitioned to CTIS with ID 2023-507632-20-00 check the CTIS register for the current data. The primary objective is to compare the efficacy of DVRd followed by cilta-cel and lenalidomide therapy versus DVRd followed by ASCT,…

A phase 3 randomized, double-blind study of ianalumab (VAY736) versus placebo in addition to eltrombopag in patients with primary immune thrombocytopenia (ITP) who had an insufficient response or relapsed after first line steroid treatment (VAYHIT2)

This study has been transitioned to CTIS with ID 2024-512890-28-00 check the CTIS register for the current data. The purpose of this study is to assess the efficacy and safety of ianalumab (VAY736) compared to placebo in addition to second-line…

Phenotyping and classifying of childhood and adult asthma exacerbations: towards future personalised treatment. An observational multicentre study.

The primary objective of the study is to determine the relationship between exacerbation treatment response at day 7 and the phenotypical characteristics of asthma exacerbations. Secondary objectives are 1) developing a prediction model based on…

Detecting cancers Earlier Through Elective plasma-based CancerSEEK
Testing - Ascertaining Serial Cancer patients to Enable New Diagnostic
II (DETECT-ASCEND 2)

The primary objective of this study is to obtain clinically characterized, whole blood specimens from subjects with a new or suspected diagnosis of cancer (cancer subjects) and from subjects who do not have a diagnosis of cancer (healthy) to develop…

The PHENOSAR trial: Antibiotic treatment of biopsy confirmed phenotypes in sarcoidosis: a proof of concept clinical trial

This study has been transitioned to CTIS with ID 2024-513534-38-00 check the CTIS register for the current data. Investigate whether treatment with azithromycin has an inhibitory effect on the mTOR pathway and/or C. acnes, causing a reduction of the…

Ototoxicity in patients with Metal-on-Metal hip Arthroplasties

To evaluate the prevalence of ocular-vestibular symptoms in patients with a (revised) MoM hip prosthesis. Our hypothesis is that patients with high plasma metal ion levels have a higher prevalence of damage to the auditory system.

A Randomized, Double-blind, Placebo-controlled Clinical Study to Evaluate Mavacamten in Adults with Symptomatic Non-obstructive Hypertrophic Cardiomyopathy

This study has been transitioned to CTIS with ID 2023-506352-24-00 check the CTIS register for the current data. Primary Objectives: • To assess the efficacy of a 48-week course of mavacamten compared to placebo on patient- reported health status (…

Clinical Outcome and Cost-effectiveness of Reduced Noradrenaline by Using a Lower Blood Pressure Target in Patients with Cardiogenic Shock from Acute Myocardial Infarction: A Multicenter Randomized Trial

This study has been transitioned to CTIS with ID 2024-510892-40-00 check the CTIS register for the current data. The objective of this study is to evaluate the (cost-)effectiveness of reduced noradrenaline in patients with CS by using a lower MAP…

Clinical Performance of Elecsys® Troponin T hs Gen 6 in Subjects with Symptoms of Acute Coronary Syndrome

To determine the clinical performance of Elecsys® Troponin Ths Gen 6 relative to the clinical diagnosis at different time points after patient admission (T0, T1, T2, T3, T6) using the previously determined universal or combined sex-specific cut-off…