791 results
Primary Objective: The main goal of this study is to provide evidence that steering saccharolytic/proteolytic fermentation by a specific indigestible fibre mixture supplemented against the background of a high-protein diet optimizes beneficial and…
This study has been transitioned to CTIS with ID 2023-506824-96-00 check the CTIS register for the current data. • safety and tolerability from baseline to week 64 in participants with hATTR or wtATTR cardiomyopathyPrimary • To compare the effect of…
The purpose of this study is to explore the efficacy and safety of LTP001 in participants with WHO Group 1 pulmonary hypertension (PH), also referred to as Pulmonary Arterial Hypertension (PAH).This proof of concept study will be executed as the…
Therefore, this study aims to improve the understanding of the physiological effect of VNS on intestinal permeability, intestinal microbiota, immunological parameters in blood and breath in drug resistant epilepsy (DRE) patients. Additionally, this…
Primary objective:To investigate the dose - (clinical) response relationship and therapeutic window of biologics in the treatment of CRSwNP.Secondary objectives:- To investigate the effect of biologics on the sensibilisation pattern of specific IgE…
To compare health-related quality of life, specifically fatigue, in melanoma patients treated with immunotherapy who use or do not use a patient-centered mobile coaching and monitoring system (CAPABLE). We expect that by using the CAPABLE eHealth…
Primary Objective:- To investigate the association between temporal evolutions of blood biomarkers and clinical adverse events, in order to produce a dynamic, individual, and accurate prediction model for patients with HFpEFSecondary Objective(s):-…
Primary Objective: Examine the accuracy of generated temperature values with three devices (Exergen, Braun and Genius) in concordance to rectal temperature in patients admitted to the Emergency Department (ED). Secondary Objective: Recommend the…
This study has been transitioned to CTIS with ID 2023-505645-12-00 check the CTIS register for the current data. Main objective: To evaluate the efficacy of BIIB122 225 mg compared with placebo.Secondary objective: To evaluate the efficacy, safety…
To examine the impact of medication induced systolic BP (SBP) reductions >=10 mmHg, while reaching a treatment target of <=140 mmHg, on cerebral blood flow (CBF) in frail elderly with untreated or uncontrolled systolic hypertension at…
This observational cohort study aims1. To identify subgroups of patients with hand and/or knee OA based on patient and disease related characteristics2. To identify subgroups of patients with hand and/or knee OA based on disease progression3. To…
• To evaluate the safety and tolerability of THB001 in cold induced chronic urticaria patients
Primary: to determine the loss of corneal endothelial cells after implantation of a Paul GDD with its tube either anterior or posterior of the iris. Secondary: to compare efficacy and safety of both procedures.
In this study we will investigate how safe the new compound Ent001 is and how well it is tolerated when it is used by healthy subjects.We also investigate how quickly and to what extent Ent001 is absorbed, transported, and eliminated from the body (…
The study aims to determine the effectiveness of the application of AET in decreasing self-reported deficits in autonomy-connectedness / self-reported symptoms of anxiety and depression in HI adults.
Comparing different ventilation strategies in focal and non-focal ARDS in invasively ventilated patients admitted to the intensive care unit.
Primary aim: To establish reference values for exercise-induced elevations of cTn concentrations following walking, cycling and running exercise. Secondary aim: Assess the prevalence of (sub)clinical coronary artery disease in individuals with high…
To evaluate the safety, feasibility and efficacy of an 8-week remotely supervised home-based maintenance exercise training program following pulmonary rehabilitation in patients with COPD.
3. STUDY OBJECTIVES3.1. Primary ObjectivesThe primary objectives are:• To determine if CAEL-101 and treatment for PCD improves overall survival in Mayo stage IIIb AL amyloidosis patients who are treatment naïve compared to treatment for PCD alone•…
The primary objective of this study is to demonstrate the superiority of etripamil NS over placebo in reducing ventricular rate in patients with AF.