101 results
Primary Efficacy Objective (Blinded Treatment Period)• To demonstrate the efficacy of rilzabrutinib versus placebo in participants with refractory/relapsed ITP, based on the durability of platelet response during the last12 weeks of the 24-week…
The aim of this study is to determine if mindfulness-based early intervention reduces internalizing symptoms in help-seeking youth and prevents their development into (serious) psychiatric illnesses. In addition we will examine putative changes in…
In the proposed study, we conduct a randomized controlled trial to evaluate the (cost-)effectiveness of ABFT compared to Treatment As Usual (TAU) on suicidality, as delivered in daily practice. We hypothesize that, compared to TAU, ABFT will lead to…
This study has been transitioned to CTIS with ID 2024-510919-29-00 check the CTIS register for the current data. OBJECTIVES - Phase 2 (not to be conducted in NL):Phase 2 Primary Objective:- Identify a setrusumab dosing strategy in subjects with OI…
The aim of this research proposal is to examine the effect of different ISIs on mTc-MEPs.Primary research question: What is the effect of different interstimulus intervals (ISIs) on mTc-MEP thresholds, peak-to-peak amplitudes, and area under the…
Primary objective of the current study is to determine the impact of intercostal nerve cryoablation on postoperative length of hospital stay compared to standard pain management of pectus excavatum patients treated with the minimal invasive Nuss…
The hypothesis is that personalised and risk-adapted treatment will improve outcome and reduce toxicity in post-pubertal patients with medulloblastoma.A further hypothesis is that clinical, magnetic resonance imaging (MRI) and voxel-based…
The purposes of this study are to uncover1. Which surgical methods are least likely to cause the CMS and if there is a difference in risk between primary surgery andreoperation2. Which patients may be genetically predisposed to developing the CMS 3…
This study has been transitioned to CTIS with ID 2023-504735-41-00 check the CTIS register for the current data. Primary for Platform-Level Exploratory Analysis1. To evaluate whether treatment with IL-23 inhibitors is superior to adult placebo in…
The primary goal of this research is to test the proof of concept of the functional prototype of the INES exoskeleton for children with CP in the clinic. In addition,the defined use cases (Donning, Doffing, Sit-to-stand, Stand to sit, Walk) will be…
Our primary objective is to determine the prevalence of exercise induced laryngeal obstruction (EILO) in children with asthma. As secondary objectives, we aim to investigate 1) if there is a different prevalence of EILO in children with and without…
The aim of this study is to identify whether the availability of a PSD for military veterans with PTSD coincides with clinically significant changes in wellbeing, behaviour and functioning in veterans and their families compared to veterans with…
The aim of the study is to gain more insight into the working factors of the Feelee app as a supportive tool to TAU in forensic outpatient settings. We examine whether the daily tracking of emotions by means of emojis together with the collected…
To determine the relationship between tissue immune responses and the clinical course of mycobacterial infections.
- special attention for the development and harmonization of the pre-analysis of liquid biopsy, for blood as well as urine, andnext to this for ctDNA- special attention for the detection of PIK3CA mutations in blood and urineSimultaneously also the…
Our first primary research objective is to investigate if and how students are changing their diet toward a more plant-based diet. Our second primary objective is to assess changes in stress by using subjective methods (questionnaires) and a…
With the extended LAST STRONG Study, we aim to (1) collect 3-year and 5-year natural history data, (2) implement the natural history data collection into clinical care and international guidelines (reach trial readiness), and (3) do in-depth…
Primary Objective: 1. The first objective of this study is to examine the evolution of pulmonary lesions on serial HRCT assessments in pediatric patients with possible or probable/ proven IA. The lesions will be measured three dimensionally and five…
The aim of our study is to investigate whether a tailored nutritional care follow-up program in children who are being discharged from the hospital with nutritional support improves nutritional intake and status as well as feeding behaviour and…
In this exploratory study we aim:1) To identify the confounding factors in qMRI analysis (e.g. age, gender, body composition)2) To determine the relation between qMRI parameters and muscle force and function taking into account the confounding…