570 results
To compare the objective response rate between patients with metastatic non-small cell lung cancer characterized by PDL-1 TPS<50% and low cTML (<300 nonsynonymous mutations) and either actionable mutation, inactivating STK11 or KEAP1…
Primary objective: To determine the characteristics of language, speech and motor functions in MCI due to AD, mild AD and moderate AD Secondary objective: To explore the association between language, speech and motor functions in MCI due to AD and…
To establish the performance of the idi-CGM system among persons with DM.
The primary objective of this study is to determine the safety and feasibility of turbine-based insufflation, measured in terms of occurrence of adverse device effects and serious adverse device effects. The secondary objectives are to determine the…
Primary objectives:- To assess the differences in resting state EEG frequency spectrum analysis between patients with neurodegenerative and patients with non-neurological causes of MCI.* Power in microvolts squared of resting stage EEG for different…
2. OBJECTIVESThe overarching goal of this proposal is to examine the feasibility and effectiveness of mobile-based screening for MDD. We combine validated screening and interventions for MDD with innovative outreach methods to maximize impact.…
The main objective is to investigate whether the additional use of IVUS leads to an increase in net lumen gain (NLG) when compared with standard angiography-guided endovascular treatment as measured during control IVUS after six weeks. Secondary…
To evaluate the effect of transcutaneous electrical nerve stimulation (TENS) in patients with ANOCA on the change in the summary score of the Seattle Angina Questionnaire (SS SAQ) after 1 month treatment with TENS, compared to baseline.
To test whether tACS in a theta frequency enhances extinction of physiological stress responses to exposure to anxiety- or trauma-related stimuli or memories. Secondarily, to examine the influence of baseline neuroendocrinological response, baseline…
Demonstrate that the self-expandable Allegra TAVI system provides lower mean gradient assessed by TTE compared to balloon-expandable valve systems in a population of all women patients with symptomatic severe aortic valve stenosis.
The aim of this study is to evaluate the validity of various algorithms for gait bout detection and spatiotemporal measures with a 3-IMU based sensor set worn on the feet and lower back. If this algorithm can be validated, it can be used to obtain…
Primary Objective: To further develop and evaluate a personalised patient-centred surveillance programme including a feedback platform for patients after curative treatment for CRC in terms of health-related quality of life (HRQoL).The goal is for…
This study will provide insights into the role of gut microbes from the upper (saliva) and/or lower GI (rectal/faecal) microbiota in the occurrence of postoperative complications in patients with resectable pancreatic and periampullary presumed (pre…
The objective of this study is to evaluate the safety and effectiveness of the PerQseal Elite vascular closure system when used to achieve haemostasis of common femoral venotomies created by 14 to 22F sheaths (venotomy up to 26F) in patients…
This study will initially focus on gaining insight into the difference between the current set PEEP level following cardiothoracic surgery compared to individually adjusting the PEEP level using EIT or Pes.
The primary aims of this study are therefore to 1) compare DmO2 derived via NIRS between young sedentary, young endurance-trained, older sedentary, and older endurance-trained subjects; 2) to compare non-invasive (i.e. with NIRS and 31phosphorous…
To investigate whether implementation of a best practice program for preoperative optimisation of patients with a focus on screening, assessment, and intervention of 8 potentially (partly) modifiable risk factors (low (aerobic) fitness level,…
To assess the effects of anesthetics on local (cerebral) microvascular parameters in craniotomy patients. Secondary objective: To assess the effects of anesthetics on systemic (sublingual) microvascular parameters in craniotomy patients.
To answer the following questions; (1) What is the estimated effect size of personalized rehabilitation therapy for improving daily functioning in severely fatigued myositis patients, compared to usual care? (2) What are the societal costs of…
The aim of this observational and exploratory study is to describe the accuracy of gaze stabilization in the presence of abnormal vestibular and visual functions. Visually induced image movements are used as the basis for gaze stability for each…