74 results
Specific Aim 1) To identify the frequency and risk factors for PVA and its subtypes in ventilated children, with a specific focus on DC breaths. Hypothesis: PVA subtypes related to inadequate ventilator support (flow undershoot and premature cycling…
To demonstrate the efficacy, safety, acceptability, and quality of life implications of Essilor® Stellest® spectacle lenses in slowing myopia progression in children and adolescents.
Primary- Does the application of Virtual Reality (VR) reduce anxiety in patients undergoing treatment for traumatic injury in the emergency department compared to patients not using VR headset? Secondary- Does the use of Virtual Reality (VR) lead to…
The main objective is to assess the perceived sound quality of different speech and music excerpts that are modified using the dereverberation algorithm by CI users. To this end a suitable graphical user interface (GUI), the MuSHRA, will be…
Primary objective of this clinical investigation is to evaluate superiority of the signal quality of SOFT ECoG flexible high-density electrode grids compared to regular high-density electrode grids, routinely used at the UMC Utrecht. The signal…
The goal of the current observational multicenter pilot study is to investigate if an 8-week Acceptance and Commitment group therapy for youth with ASD is an effective intervention to increase adaptive emotion regulation, psychological flexibility…
The main objective is to determine genetic phenotype and the prevalence of anti-HLA (human leucocyte antigen) and anti-HPA (human platelet antigen) antibodies in patients with Glanzmann thrombasthenia.
1. Distinguish and characterise linguistic voice-types2. Examine differential working mechanisms of voice-types3. Exploratively evaluate the role of voice-type in treatment effectiveness4. Disseminate the results to clinicians and voice-hearers
The aims of this study are:1. To describe the neuropsychiatric profiles associated with DDX3X syndrome, SETD1A syndrome, Koolen-De Vries syndrome, KBG syndrome, DYRK1A syndrome, Jansen-De Vries syndrome, Gabriele-De Vries syndrome, and Smith-Magenis…
Primary Objective: To explore the acceptability and feasibility of rTMS added to exposure with response prevention and/or medication as an intervention in youth with OCD and/or GTS. Secondary Objective(s): - To explore the effects of added rTMS on…
Primary Objective:1) To determine the efficacy of personalized progressive resistance training (PRT) on muscle strength of elbow flexors in children and adolescents with Spinal Muscular Atrophy and Congenital Myopathy compared to usual care…
The aim of this study is to assess the clinical suitability of PEEK bonded retainers and to evaluate its successes and failures compared to the current clinical *golden standard* multibraided stainless steel bonded retainer wires.Null Hypothesis:…
Identification of possible genetic modifiers, that will advance the knowledge on the pathomechanisms of aortopathy.Hopefully this will offer promising new leads to novel therapeutic that will allow to individualize current treatment protocols to…
In this project, we will conduct research within a learning and development framework to explore the barriers in adult mental health care (V-GGZ) and how and when screening and monitoring for KOPP (Children of Parents with Psychiatric Problems) can…
A pilot study to understand the transmission dynamics of RSV in households and potential reduction of viral transmission.
The primary objective of this study is to investigate the efficacy of EMDR therapy in reducing pain interference in the life*s of children with SCD. Secondary objectives are to study the efficacy of EMDR in reducing PTSD symptoms, anxiety,…
The goal is to study the genetic background of childhood glaucoma in the Netherlands. We aim to study which mutations play a role in the pathogenesis of childhood glaucoma in the Netherlands and their prevalence. We will study the genetic mutations…
The proposed study aims to examine the efficacy and process of an individualized (vs. standardized), comprehensive and family-centered neuropsychological intervention for pediatric brain tumor patients experiencing neuropsychological problems. The…
The primary objective is to:a) examine the reliability and validity of the adapted PAT. Secondary objectives are to:b) examine agreement and possible differences between PAT scores of mothers and fathers, and between patients and partners.c) examine…
PrimaryInvestigate the seroprevalence of pre-existing antibodies to AAV in patients with PKP2-associated ARVCSecondaryTo characterize the burden of illness in patients with pathogenic or likely pathogenic PKP2 mutationsTo characterize arrhythmic…