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Immersive VR after cardiac surgery with thoracotomy, a feasibility study

To investigate whether the use of VR is feasible in patients after coronary artery bypass graft surgery (cardiac surgery with thoracotomy)

Diaphragm paralysis: Surgery or mechanical ventilation?

The following questions will be addressed in the PARASOL study• What is the effect of plication or non-invasive mechanical ventilation on the EQ-5D-5L? o The pilot study is needed as we do not know the clinical relevant effect of both therapies on…

Study into the feasibility and effectiveness of a personalised lifestyle intervention (LEEV!-intervention) in achieving long-term lifestyle improvement in adults with intellectual disabilities

Primary objective:Can a personalised lifestyle intervention (LIFE-ID intervention) support healthcare professionals in achieving effective and long-term lifestyle improvement (increased physical activity) for adults with ID to improve their&…

Evaluation of cardiac troponin dynamics as an early biomarker for anthracycline-induced cardiotoxicity

Identification of the dynamics of hs-cTnI and hs-TnT release during and after anthracycline treatment (doxorubicine in combination with cyclofosfamide) in breast cancer patients in order to determine the optimal sampling time point, most reflective…

Sleep as an additional painkiller

The objective of the study is to investigate whether adding i-CBT-I at the start of standard pain treatment can enhance pain healthcare by reducing patient suffering and costs compared to Treatment As Usual (TAU). Our analyses will examine whether…

Cost-effective application of seizure detection devices for high-risk night-time epileptic seizures

The objective of this study is to determine what the differences are between care as usual and care where a seizure detection device is used in addition to care as usual. Specifically, this study will compare the number of missed and correct visits…

PReoperative Optimisation of Modifiable rIsk factorS in surgEry of the Pancreas:
the implementation of best practice before pancreatic resection

To investigate whether implementation of a best practice program for preoperative optimisation of patients with a focus on screening, assessment, and intervention of 8 potentially (partly) modifiable risk factors (low (aerobic) fitness level,…

A Pre-Market, First-In-Human, Pilot, Interventional, Clinical Investigation to Evaluate the Safety of the Aqua Therapeutics Thermal Therapy Vapor Ablation System (ATTTVAS) in premenopausal women with Abnormal Uterine Bleeding (AUB).

Primary ObjectiveTo evaluate the safety of the Aqua Therapeutics Thermal Therapy Vapor Ablation System (ATTTVAS).Secondary Objectives1. To evaluate the change of menstrual blood loss (MBL).2. To evaluate the effect of MBL on the quality of life (…

Luchtbrug Junior: The next step

The aim of this project is to test the hypothesis that symptom-free days (SFDs) of children with preschool wheezing can be increased using Luchtbrug Junior, while reducing regular outpatient visits by 50%.

Investigating the effect of the digital Patient Benefit Assessment Scale, a goals-based tool, on patient-centred outcomes in the healthcare process.

To measure the effect of the digital picture based Patient Benefit Assessment Scale on patient-centred outcomes regarding their health care process, the first eight domains of the factor health care process of the PPPC-R questionnaire (appendix 2)…

CAtheter-Based Ablation of atrial fibrillation compared to conventional treatment in patients with Heart Failure with Preserved Ejection Fraction - Investigator-initiated, prospective, parallel-group, randomized, open, blinded endpoint assessment (PROBE), interventional multicenter strategy trial

The objective of CABA-HFPEF is to assess whether catheter ablation (CA) for atrial fibrillation (AF) can prevent adverse cardiovascular (CV) outcomes in patients with heart failure (HF) with preserved or mildly reduced ejection fraction (HFpEF or…

Serum urate home monitoring for gout using a Point-of-Care Testing Meter and nurse-led treat-to-target approach: A feasibility study

This research aims to examine the feasibility of home monitoring of serum uric acid for both patients and stakeholders, using a digital home measuring device in conjunction with a nurse-led T2T approach.Primary research question:What is the…

Research into the shorter and longer term effects of two low-intensity exercise programs in people with type 2 diabetes mellitus (T2DM)

see also aboveThe aim of the project is to investigate the effects of an accessible 20- and 50-week walking intervention for people with diabetes. This examines the level of physical activity, quality of life, patient activation, diabetes self-…

The effect of dried chicory root on inflammation, gut microbiota and complaints in patients with Inflammatory Bowel Disease: a pilot study

Primary Objective: To explore the effect of a 4-week 10-20 g/day WholeFiberTM intervention on fecal calprotectin levels in patients with CD and UC.Secondary Objective(s):- To explore the effect of a 4-week WholeFiberTM intervention on stool pattern…

ABI-aftercare in motion: Multidisciplinary aftercare in the home environment in patients with acquired brain injury

To improve aftercare for patients with ABI receiving outpatient rehabilitation, aimed at promoting an active lifestyle to prevent persistent complaints after ABI and poor HR-QoL.

Cohort multiple Randomized Controlled trial in pediatric asthma: infrastructure to assess the long- and short-term effects of (eHealth) interventions

CIRCUS cohort:This study aims to provide a framework to assess the effect of (eHealth) interventions and generate short- and long-term data on clinical and patient-reported outcomes of asthmatic children using a cohort multiple Randomized Controlled…

Precision use of Antibiotics in Infected Necrotizing Pancreatitis

The primary objective is to determine whether implementation of a best-practice protocol focused on antimicrobial stewardship in Dutch hospitals is non-inferior compared to standard care on mortality and major complications in patients with acute…

Cognitive Flexibility and Creativity in People with Parkinson*s: A Pilot Study Exploring the Influence of Dopaminergic Regulation on Cognitive Flexibility and Creativity, with an Emphasis on Visual Art

Our main objective is to conduct a pilot study testing the applicability and face/external validity of the battery in a young-onset PD cohort, alongside age-matched healthy controls. We aim to gain deeper insights into the complex interrelationships…

The effect of an extended use of enteral tube feeding sets on growth of microorganisms

Primary objective of the study is to determine whether prolonged use of 96 hours leads to growth of microorganisms (type and numbers (CFU/ml)) in enteral tube feeding sets. Secondary objectives are the occurrence of gastrointestinal events/ new…

Preservation of fertility in female AYA cancer patients: needs assessment, fertility, and quality of life in cancer survivors; 2-PREFER study

Determine AYA*s experiences and needs related to FP(C) and follow-up care after FP(C) (Q1); determine the number of AYAs pursuing to conceive and their fertility and obstetric outcome(s) after FP(C) after gonadotoxic treatment (Q2); determine…