238 results
To identify an AAA associated genes by a functional candidate gene approach.The identification of an AAA associated gene will have several impacts on this high prevalent disease:1. It will improve our understanding of the molecular pathways involved…
This study aims to identify the relationship between candidate genes such as for instance BDNF, 5-HTTLPR, DAOA, G72, DTNBP1, NRG1 and COMT with cognitive function and emotional- and behavioural traits.
The main objective of this specific study is to examine to what extend differences in cognitive functioning between people are due to complex interactions between genes and environment.
In the first place, we will collect tissues from over-reacting patients, including a thorough quality assurance program. Thereafter, we will identify the gene profiles of the patients that exhibit extreme radio-sensitivity without known hereditary…
Development, optimization and implementation of retro-orbital fibroblast cultures in our laboratory.
In the present study we will assess the associations between the nutritional status of Hindustan pregnant women on the one hand and anthropometric and metabolic parameters of their neonates on the other hand.
The primary objective of this study is to identify mutations associated with the development of a bicuspid aortic valve. To this end the study will focus on genes important for aortic valve formation. As an extension of the primary objective, a…
1. The primary aim of the study is to investigate whether periodontal treatment results in a decrease of plasma biomarkers that are related to cardiovascular diseases (CVD) and metabolic syndrome (MS) and what is the effect of the treatment on the…
The research is set up to investigate three primary questions.1. Is there a difference between bone resorbing capacity between postmenopausal women with a vertebral fracture and postmenopausal women without a vertebral fracture and high bone mineral…
The objective of the study is to get more insight into the interpretation of multiplex PCR test (which are so sensitive, that falls positive samples due to colonisation, or interpretation problems due to mixed infection may occur) and to expand a…
RationaleSince gamma band activity is thought to be an important mechanism in perceptual binding and cognitive function, interest in changes in gamma band activity in neuropsychiatric disorders has grown rapidly. Changes in gamma band oscillations…
Within the observational study WP9, there will be 3 substudies. First the microbiological aetiology of LRTI will be studied by comparing test results in 3000 healthy controls to findings in 3000 adults with LRTI. Bacterial resistance rates will be…
Aim of this study is to explore the relation between Th1-cell mediated diseases as psoriasis/psoriatic arthritis and Th2-cell mediated asthma, allergic rhinoconjunctivitis, atopic dermatitis and hand eczema. Question is whether a dysbalans in…
The major research objective is:Does a switch from a low-fat to a high-fat diet lead to a reduced hepatic and skeletal muscle insulin sensitivity due to an increase lipid accumulation in liver, skeletal muscle and heart? Secondary research…
To obtain insights into the diverse nuclear receptors involved in the regulation of the bile acid cycle across the entire human gastrointestinal tract. Amendement:The aim of our study is to investigate the expression and amount of expression of HIF-…
The objective of this study is to identify determinants, to determine the transmissibility and to determine the burden of disease of NT-MRSA and CA-MRSA carriage compared to other typeable MRSA strains in the community.
The aim of the study is to check if the mood-as-input model can give a possible explanation for the persistence behaviour seen in patients with work related upper extremity pain. Because of the fact that the mood-as-input model is only tested in non…
To establish the accuracy and precision of systolic cardiac time intervals and arterial pulse wave velocity as obtained from multiple M-mode carotid artery ultrasonography. And to test whether the non-invasive tonometer pressure waveform is…
The present study will examine how young-onset-dementia patients and their families can be supported in their home environment as long as possible and institutionalisation can be delayed. For this the functioning and care needs of young-onset-…