142 results
To develop a model that predicts the probability of pathologic complete response to nCRT in esophageal cancer, by integrating diffusion weighted magnetic resonance imaging (DW-MRI) and dynamic contrast enhanced magnetic resonance imaging (DCE-MRI)…
This study has the following objectives:1) To assess if dEMG measurement is feasible during pulmonary transition in the delivery room* Does the signal quality (expressed in heart rate and respiratory rate) of dEMG during the transition agree with…
The goal of this study is to investigate the efficacy and cost-utility of Oncokompas among patients with incurable cancer compared to care-as-usual. The main hypothesis is that use of Oncokompas will be superior to care as usual to improve patient…
1. To assess serum calcification propensity (T50) in SSc patients compared with healthy age and gender-matched controls; 2. To assess serum T50 in SSc patients with overt calcinosis cutis as compared to age and gender-matched SSc patients without; 3…
Primary Objectives* To characterize patients with unipolar depression in terms of social, physical, biometric activity, and neurophysiological and -psychological data outcomes using digital technologies * Evaluating the feasibility and subjective…
Primary Objective: To assess whether CYP450 genotype guided dosing of TCAs results in faster attainment of therapeutic plasma concentrations compared to dosing as usual. . Secondary Objectives: * To assess whether genotype guided dosing results in…
In this study we aim to investigate prognostic factors by adding extra questionnaires for patients and their caregivers, observation list and the use of an accelerometer. These variables can provide information about the successful as well as non-…
Migration in Total Hip Arthroplasty with a Cemented BiMobile cup: Better stability with more cement?
The main objective of this study is to compare the (early) migration of the cemented BiMobile cup at two year post-surgery between 2 different cup sizes after standard optimal reaming, and therefore adjusting the amount of cement into 2 or 4…
Primary Objective: To determine if the (change in) gut and oral microbiome at baseline or in the first 3 months after start of Cladribine is a predictor for treatment response in subjects with active relapsing remitting MS.The secondary objectives…
Primary Objective: The primary objective is to develop supervised algorithms for the classification of motor intentions for different activities of daily living. These algorithms are developed for both bipolar surface electromyography as well as…
Our main objective is to assess QoL and disease-specific symptoms over time. Our secondary objectives are to identify demographic, environmental, biological, physiological and personality characteristics of TC patients who are at high risk for poor…
The aim of this study is to develop and evaluate a new ultrasound-based navigation system for guidance of resection and ablation of liver lesions during liver surgery. The feasibility and accuracy of this in-house developed navigation system is…
The primary objective is to investigate whether there is a difference in the number of hip dislocations and revisions following primary total hip arthroplasty (THA), using the posterolateral approach, with a DM cup compared to a unipolar cup in…
The first objective of this study is to provide a detailed, quantitative and qualitative description of early language development (*developmental language profile*) in children with 22q11DS, comprising expressive and receptive abilities, covering…
The primary objectives of this study are the following:* To prospectively characterize CEP290-related retinal degeneration and the clinical phenotype of participants with light perception to 20/50 visual acuity and with either compound heterozygous…
The purpose of this study is to evaluate the feasibility and efficiency of transducing freshly obtained CD34+ HSC from either mobilized peripheral blood or bone marrow of healthy donors using lentiviral SIN vectors encoding codon-optimized human…
We aim to determine the impact and seriousness of other TBDs in the Netherlands by measuring the prevalence and describing the clinical picture and the course of different other TBDs.
The aim of the proposed study is to investigate the presence of dopaminergic abnormalities, as measured with [11C]raclopride, in relation to antipsychotic medication discontinuation in patients remitted after a first-episode psychosis (FEP).…
Primary Objective: To determine the effect of sex hormones on bone marrow fat. and visceral fatSecondary Objective(s): * To determine the effect of sex hormones on visceral and liver fat.* To test whether DXA can be used to calculate the amount of…
To study the effect of immune modulating therapies, including anti-CTLA4, anti-PD-1, anti-PD-L1checkpoint inhibitors, and TIL therapy, on the composition and activation of systemic and local immunity, with an emphasis on the size and diversity of…