123 results
Determination of the individual genotypes for drug metabolizing enzymes and transporters among volunteers, in order to design dedicated clinical trials in a subpopulation, for (potential new) drugs that are substrates, inducers or inhibitors of…
*Premature infants and maternal pertussis immunization. Is second trimester vaccination beneficial?*
Our primary objective is to evaluate non-inferiority of anti-Pertussis Toxin (PT) IgG in term infants at 2m of age born of mothers having received a pertussis vaccine between 20-24w Gestational Age (GA) compared to a reference anti-PT IgG at 2m of…
To investigate neural response patterns to visually and orally presented palatable (high vs low caloric) and unpalatable (high vs low caloric) foods in AN patients and matched healthy controls (HC). This will be investigated through 1 study with 2…
The goal of this study is to assess the repercussions of juvenile vulvar lichen sclerosus as an adult, and to improve care after the diagnosis of JVLS has been made.
To evaluate the natural progression of anatomical and functional visual parameters in genetically defined subjects with Geographic Atrophy (GA) due to Age-related Macular Degeneration (AMD).
The main objective of this study is to determine the effects of 8 weeks aerobic exercise pre-conditioning (to improve muscle fiber perfusion capacity) on the increase in skeletal muscle mass and function during 12 weeks of resistance exercise…
To study the effect of deep neuromuscular block compared to standard neuromuscular block on intra-operative adverse events during laparoscopic surgery using the CLASSIC score system.
To obtain fresh mononuclear cells from healthy volunteer donors to be used for validation of procedures for the generation of GMP-grade T cell or tolerogenic dendritic cell products for clinical application.
The course of cognitive functioning in the first year after an out of hospital cardiac arrest (OHCA)
The general aim of this study is to investigate the course of cognitive functioning during the first year after an OHCA. In order to find correlations which might suggest treatable causalities, cognitive functioning will be linked to parameters…
Main objectives: To determine the changes in structural and functional measures over a two-year time period in healthy elderly volunteers, and to determine the association between structural and functional changes.Secondary objectives: Magnitude of…
This project aims at identifying and characterizing these maps and their properties and roles in the human brain.To this end, we will employ pRF mapping (Dumoulin and Wandell 2008) which provides a biologically plausible means to characterize the…
This protocol serves to establish a formal procedure to allow collection of blood samples from healthy volunteers within the Department of Internal Medicine to be used for development and/or optimization of transplantation-related in vitro assays
The primary objectives are to:1) Adapt and optimize sequences and protocols to enable acquisitions during exercise with MRI and/or surface EMG.2) Perform a study in healthy volunteers using the sequences and protocols developed in 1) to correlate MR…
Objective: The primary objective is to investigate the digestibility of isolated duckweed protein and the isolated benchmark protein whey.
Objectives: - To identify and compare motivational behaviour in patients during different phases of cancer treatment. - To test its associations with self-reported fatigue/depression. - To determine to what extent treatment regimen, inflammation,…
The primary goal of this study is to gain a better understanding of how dementia affects the multimodal expression of emotions in face, gestures, verbal and non-verbal expressions when discussing emotional laden autobiographical memories. Therefore…
Objective: The aim of this study is to evaluate if an adequate level of bowel cleansing can be achieved with the Pure-Vu in patients with previous poor bowel preparation (Boston Bowel Preparation Scale [BBPS]<6).
This study aims to investigate if and how synaptic density may underlie cognitive deficits and whether functional connectivity is the intermediate step. In patients with psychotic disorders, cognitive function and brain connectivity may be decreased…
To determine if short-term treatment with the selective beta-2-adrenergic agonist clenbuterol improves glucose disposal via the mTORC2 pathway in lean, healthy male individuals with normal physical activity
Evaluation of the change in health-related quality of life (HRQoL) and physical and mental health of critical illness survivors.