123 results
The primary objective is to investigate the resting energy expenditure of children with a hematological, solid or brain malignancy at diagnosis and during treatment. The secondary objective is to explore the body composition, physical activity and…
Determine the B-cell antibody response in patients with Staphylococcus aureus, Klebsiella pneumoniae and Escherichia coli bacteremia
The primary aim of the study is to compare the effect of PRO symptom monitoring with standard care on QoL both during and up to 1 year after treatment. Secondary aims are studying the effect of PRO symptom monitoring compared to standard care on the…
Aim and Objectives The overall aim is to define the broad disease spectrum of cysteine altering NOTCH3 mutations, specifically the as yet unexplored milder end of this spectrum, and to determine to what extent the mutation position predicts disease…
To identify correlations between immune changes at the cellular or molecular level in the serial FNAB and blood samples before and after withdrawal of treatment, and * in case of relapse - to identify correlations between the degree of immune…
The objective of this study is to validate a novel MRS-based method to quantify NAD+ by selectively suppressing the coupled α-ATP spin system, which is overlapping with the NAD+/NADH signals in vivo. For NAD+/NADH quantification to be valuable in…
1. To quantify brain iron accumulation in patient with HD using quantitative susceptibility mapping (QSM) at ultrahigh field (7T) as compared to healthy controls (case-control design).2. To link QSM results with specific and well-known clinical CSF…
With this study we want to investigate whether the use of a dietary supplement during immobilization can decrease the loss of muscle mass and strength during immobilization and augment the rate of muscle mass re-gain during recovery.
Primary objective: To assess NCF, HRQoL, mood, fatigue, cognitive complaints and health care utilization in long-term surviving patients with anaplastic oligondendroglioma and oligoastrocytoma.Secondary objective:To assess cerebral abnormalities in…
The primary objective is to investigate whether Parkinson*s patients are able to produce an optimal inhalation technique for the Cyclops® inhaler in their home situation after first and second inhalation instruction. The secondary objective is to…
The main objective of this trial will be to get a better insight in the influence of age and age-related changes by internal and external factors on vaccine-induced immune responses and gain knowledge on the trajectory of immune decline in older…
In one of our previous study we demonstrated that enhanced acetate availability in the distal, but not proximal, colon promote fat oxidation, energy expenditure and parameters of substrate and energy metabolism in healthy normoglycaemic men. In…
- To identify the relationship between fatigue and effort-based decision making in cancer survivors- To test whether effort-based decision making differs between cancer survivors and controls
Primary objective: To classify the effect of the pharmacogenetic profile of CYP2C19 and CYP2D6 in HD gene carriers, compared to more classic medication prescribing parameters (such as age and comorbidities) on negative medication effects of HD-…
This research project examines whether: -susceptibility to nocebo effects predicts future pain progression in patients with chronic widespread pain, i.e. fibromyalgia (part 1), - nocebo-related learning processes differ between patients and healthy…
To assess the timed effects of a matched acute oral sodium load (in the absence or presence of GLP-1 receptor agonist) or an acute intravenous sodium load in T2DM patients with/without renal impairment on urinary sodium excretion after 24h,…
The objectives of this study are to acquire PPG data in patients during an ablation procedure simultaneously with reference measurements (ECG, ABP), investigate differences in PPG measurement between patients with failing and non-failing hearts, and…
Compounds targeting the 17β-HSD type 1 enzyme are close to the first human trials.To best design future human trials it is important to characterise the intra & inter patient variability of 17β-HSD-1 and other enzymes involved in the local…
1. Evaluation of the variation of semen characteristics in the general population2. Evaluation of the variance of testosterone levels in the general population
To determine the workability of the non-invasive abdominal electrode patch for implementation in clinical practice.