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Celiac disease: interplay between genes and the environment. Towards the unraveling of disease initiating events.

The primary oblective of the study is to elucidate all molecular mechanisms leading to coeliac disease.In order to establish the scientific basis for the development of improved diagnostics, novel therapies and safer foods for patients, in the CDC:…

Sjogren-Larsson syndrome, clinical aspects

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Genetics of childhood obesity

We propose that variation in genes involved in the regulation of motivational behaviour and satiety plays a major role in the development of obesity. We aim to identify these genes using family-based association and linkage analysis in a large…

The role of visual complexity in the development of typical and autistic children. A: children 1- 4 years old

The overall aim of this prospective study is identifying early markers for Autistic Spectrum Disorders by following the developmental track of visual perception in normal and abnormal development, eventually leading to a basis for effective…

Phase II single-arm studies of gemcitabine in combination with oxaliplatin in refractory and relapsed pediatric solid tumors

To assess the response rate to the combination of gemcitabin plus oxlaiplatin in 5 different strata of relapsed/refractory pediatric solid tumors, in whom standard treatment has failed. Secondary objectives are the safety, the duration of response,…

Genetic studies in patients with nonsyndromic orofacial clefts.

Assembly of a large sample of patients/families with nonsyndromic oro-facial clefts from Central Europe for identification of genetic factors responsible for this phenotype by usage of association and linkage disequilibrium studies.

Cost-effectiveness of the Demands and Capacities Model based treatment compared to the Lidcombe programme of early stuttering intervention: Randomised trial

To evaluate the cost-effectiveness of the Demands and Capacities Model based treatment (Dutch standard) compared to the Lidcombe programme for early stuttering intervention.Follow-up: Long-term outcome, taking into account recent genetic findings.

Effects and health economic aspects of enzyme therapy in children and adults with Pompe disease. Long-term follow-up of patients receiving commercially available Myozyme

This study has been transitioned to CTIS with ID 2024-518269-92-00 check the CTIS register for the current data. The objective of the study is to gather more information about the long-term effect of enzyme therapy in patients with Pompe disease…

National study of moderate and severe von Willebrand disease in the Netherlands

The objective of this study is to assess the clinical presentation, the treatment and the complications of treatment in moderate and severe von Willebrand disease. Another goal is to investigate the influence of von Willebrand disease on quality of…

Monitoring project on human avian influenza (AI) infections in contact with AI-infected animals

In addition to the aforementioned passive monitoring of high-risk persons with respiratory complaints after exposure to HPAI, this project aims to set up active monitoring (exclusion diagnosis) in high-risk persons without respiratory complaints in…