1376 results
The primary efficacy objective for this study is to evaluate the efficacy of RO7234292 compared with placebo.The secondary efficacy objective for this study is to evaluate the efficacy of RO7234292 compared with placebo.The safety objective for this…
Objective: 1. To determine whether vascular reactivity is lowered in memory clinic patients with mixed and pure AD pathology. 2. To define whether vascular reactivity upon visual activation is associated with CAA or with other small vessel disease (…
The aim of the current study is to evaluate the efficacy and cost-effectiveness of NKI followed by EBD compared to standard EBD in patients with recurrent esophagogastric anastomotic strictures. The combination of NKI and EBD is estimated to achieve…
We aim to determine the validity of the steep ramp test as practical performance-based aerobic capacity test in patients undergoing elective colorectal resection by correlating the tests* scores with the ventilatory anaerobic threshold and oxygen…
The primary objective of the proposed study is to test the efficacy of personalized psychological care for improving functioning in cancer survivors with severe and persistent depressive and/or fear of cancer recurrence and/or cancer-related fatigue…
To record and analyse the electrophysiological properties and differences of the human pituitary gland, i.e. the anterior lobe, posterior lobe and adenoma.
The main objective of this study is to evaluate if systemic exposure of osimertinib (i.e. AUC) is enhanced when osimertinib is co-administered with cobicistat in patients with relatively low blood concentrations while receiving the standard…
Primary Objective: - to establish if a gut microbiome perturbation affects APS disease phenotype.Secondary Objective(s): - to identify biomarkers that are responsive gut microbiome perturbation.- to establish if gut microbiome perturbation affects…
This study has been transitioned to CTIS with ID 2024-513374-22-00 check the CTIS register for the current data. 5.1 Primary ObjectiveTo evaluate the long-term safety of glepaglutide treatment in SBS patients.5.2 Secondary ObjectivesTo evaluate the…
To increase the one year anastomotic integrity rate in patients undergoing total mesorectal excision (TME) for rectal cancer by the routine and quality controlled implementation of a multi-interventional program, which includes:1. MBP with oral…
1. To study effectivity of the epidural injection with analgesic and anti-inflammatory medication to relieve the symptoms within two weeks follow up.It will be evaluated in what percentage of patients the decrease in leg pain is satisfactory in both…
This study has been transitioned to CTIS with ID 2023-503829-18-00 check the CTIS register for the current data. Primary objectives:- To assess in a randomized comparison the effect of midostaurin added to 10-day decitabine treatment on the…
To determine the effect and acceptability of a three-session reactive balance training intervention with CAREN, on balance control measured with the mini BESTest in community-dwelling older adults (>=65 years) who visit the trauma outpatient…
Primary objective:* To evaluate the efficacy of norursodeoxycholic acid (norUDCA) 1500 mg vs. norUDCA 1000 mg vs. placebo for the treatment of NASHSecondary objectiveTo study safety and tolerability (adverse events [AEs], laboratory parameters) of…
The primary objective is to investigate the feasibility of using counterconditioning as a novel treatment method aimed to reduce pain in female fibromyalgia patients.
Primary objectives are:1. Are there differences in complication rates between patients treated with harvesting of bone from the iliac crest and patients not treated with bone grafting during open wedge corrective osteotomy and plate fixation of the…
The purpose of this scientific study is to verify whether immunotherapy (L19-IL2) after a standard treatment such as radiotherapy, fights the metastatic disease more efficiently than the current standard treatment alone.
This study has been transitioned to CTIS with ID 2023-508726-10-00 check the CTIS register for the current data. Objectives of the studyPrimary ObjectiveTo compare recurrence-free survival (RFS)(based on BICR assessment) of nivolumab versus placebo…
This study has been transitioned to CTIS with ID 2024-515186-33-00 check the CTIS register for the current data. The three key outcome measurements and challenges of this proof of concept study are to achieve a decrease in ongoing HO bone formation…
Main objective is to determine whether patients have a better recovery after laparoscopic sterilization or a diagnostic laparoscopy under conscious sedation compared to general anesthesia as measured with the QoR-40 one day after surgery.