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A phase 3, randomised, double-blind, multi-centre trial to evaluate the efficacy,
safety, and tolerability of brodalumab treatment compared to placebo (blinded) and
ustekinumab (open-label) in adolescent subjects (12-17 years of age) with
moderate-to-severe plaque psoriasis

To determine the efficacy of subcutaneous administration of brodalumab compared with placebo in treating adolescents with moderate-to-severe plaque psoriasis.

ON-SCENE Initiation of Extracorporeal CardioPulmonary Resuscitation During Refractory Out-of-Hospital Cardiac Arrest

In this study, we aim to improve survival to hospital discharge and costs/QALY in young patients with OHCA by decreasing the time in cardiac arrest by initiating ECPR on scene.

Near-infrared fluorescence imaging using indocyanine green as an adjunct to improve standard-of-care sentinel lymph node procedure in pediatric patients with melanoma or sarcoma of head/neck/trunk, paratesticular or extremities: a feasibility trial

To determine the feasibility of using ICG to optically guide the surgeon to the SLN of paediatric melanoma and sarcoma patients. The SNP is a diagnostic procedure.

Respiratory muscle training in patients with Spinal Muscular Atrophy

The aim of this study is to assess the feasibility and efficacy of respiratory muscle training (RMT) in patients with SMA and respiratory muscle weakness.

An open label, long term safety trial of spesolimab treatment in patients with fistulising Crohn*s disease who have completed previous spesolimab trials.

1. To evaluate the long-term safety of spesolimab in patients with fistulising Crohn*s disease who have completed treatment in previous trials.2. To evaluate the long-term efficacy of spesolimab in patients with fistulising Crohn*s disease who have…

A Randomized Phase III Trial of Stereotactic Ablative Radiotherapy for the Comprehensive Treatment of 4-10 Oligometastatic Tumors (SABR-COMET 10)

To assess the impact of SABR, compared to standard of care treatment, on overall survival, oncologic outcomes, and quality of life in patients with a controlled primary tumor and 4-10 metastatic lesions.

THE IMPACT OF HIGH VERSUS STANDARD ENTERAL PROTEIN PROVISION ON FUNCTIONAL RECOVERY FOLLOWING INTENSIVE CARE ADMISSION: A RANDOMIZED CONTROLLED, MULTICENTER, PARALLEL GROUP TRIAL IN MECHANICALLY VENTILATED, CRITICALLY ILL PATIENTS

To investigate whether increased protein provision in critically ill patients during Intensive Care Unit (ICU) admission can improve functional outcome and recovery following ICU discharge

A First-in-Human, Randomized, Double-Blinded, Placebo-Controlled Trial in Healthy Subjects to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Single and Multiple Ascending Intravenous Dose Levels of ARGX-117 and Subcutaneous Dose Levels of ARGX-117 Co-Mixed with Recombinant Human Hyaluronidase PH20

This is the first clinical study in which ARGX 117 is administered to humans. The purpose of this study is to investigate how safe the new compound ARGX-117 is and how well it is tolerated when it is administered to healthy volunteers. It will also…

(Cost-)Effectiveness of local corticosteroid injection versus exercise therapy for shoulder complaints: a pragmatic randomized, 12 months comparative parallel-group trial

We will evaluate the clinical and cost-effectiveness of the two guideline recommended treatments for patients with persisting shoulder pain over a 12 month time period. Patients will be randomized to a local corticosteroid injection or referral for…

The role of sex hormones in the provocation of migraine attacks in female migraine patients

To compare serum estradiol levels during the late luteal phase between 1) women with menstrually-related or pure menstrual migraine and premenopausal controls and 2) perimenopausal migraine patients and perimenopausal controls. Secondary objectives…

Assessment of Safety, Tolerability, and Efficacy of Donanemab in Early Symptomatic Alzheimer*s Disease

This study has been transitioned to CTIS with ID 2023-507303-55-00 check the CTIS register for the current data. To assess the effect of donanemab versus placebo on clinical progression in participants with early symptomatic AD with demonstrated…

Study to Evaluate Boston Scientific VerciseTM CartesiaTM 16-contact Directional Lead (X/HX) with Deep Brain Stimulation (DBS) Systems for the treatment of Parkinson*s Disease (PD)

To document patient outcomes including effectiveness for Boston Scientific Corporation*s VerciseTM CartesiaTM 16-contact Directional Lead (X/HX) with Deep Brain Stimulation (DBS) Systems for the treatment of Parkinson*s Disease (PD).

BALANSEAT
RCT study on seated balance training with the Balanseat device in older people

The main objective of the proposed study is to evaluate if the Balanseat (used as intended) is feasible when only minor involvement from a therapist is required, contributes to therapy adherence and improves gait and balance compared to usual daily…

An Open Label, Phase 1/2a Trial to Evaluate the Efficacy, Safety, and Tolerability of KU002 Given as Intravesical Instillations in Subjects with Interstitial Cystitis (IC)/Bladder Pain Syndrome (BPS)*

Primary Objective:The primary objective of this study is to evaluate the safety, tolerability and PK profile following intravesical administration of KU002 in subjects with a diagnosis of BPS/IC.Secondary Objective(s):The secondary objective of the…

Efficacy and safety comparison of brodalumab versus guselkumab in adult subjects with moderate-to-severe plaque psoriasis and inadequate response to ustekinumab; COBRA

Primary objectiveTo compare the efficacy of brodalumab with guselkumab in adult subjects with moderate to severe plaque psoriasis and prior inadequate response to ustekinumab. Secondary objectives:To evaluate the efficacy of brodalumab compared with…

Non-invasive characterization of paediatric brain tumours using metabolic imaging at high magnetic field

To determine whether metabolic imaging at 7 Tesla is feasible and suitable to detect changes in phospholipids and APT levels in paediatric brain tumours.

High Flow Nasal Cannula versus Low Flow Nasal Cannula in patienst with atrial fibrillation undergoing point-by-point catheter ablation under deep sedation.

To test the effect and incidence of hypoxemia when oxygen supplementation through HFNC as compared to LFNC in patients with atrial fibrillation undergoing point-by-point ablation (like RFCA or Galaxy PFA) and deep sedation.

Mapping the peritoneal immune system to identify novel immunomodulatory treatment options for diseases with peritoneal involvement.

AimThe MAPS study aims to unravel the immune composition of the human peritoneal cavity and the tumor immune environment in peritoneal metastasized gastric and colorectal cancer. The overarching aim is to find new targets for immunotherapy for this…

AN OPEN-LABEL, EXPLORATORY STUDY ASSESSING THE FEASIBILITY OF SGM-101, A FLUOROCHROME-LABELED ANTI-CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY FOR THE INTRAOPERATIVE DETECTION OF LUNG METASTASIS IN COLORECTAL CANCER

1. To determine the feasibility of SGM-101 for intraoperative imaging of colorectal lung metastases - Concordance between fluorescent signal and tumor status of resected tissue2. To define the optimal dose of SGM-101 for intraoperative imaging of…

A Phase Ib, multicenter, open-label dose escalation and expansion platform study of select druk combinations in adult patients with advanced or metastatic BRAF V600 colorectal cancer.

Primary objective:To characterize safety and tolerability of each treatment arm tested and identify recommended doses (RD) and regimens for future studies, by assessing the incidence and severity of AEs and SAEs; including changes in laboratory…