3434 results
To assess the feasibility and safety of using a combined sponge-methylation biomarker strategy in detection of Barrett*s Esophagus, (early) esophageal cancer and detection of locoregional regrowth after nCRT.
To evaluate the safety of EndoArt® in subjects with chronic corneal edema.
The primary objective of the study is to predict the effect of a given ecological momentary intervention (either ReApp or Imager) based on acquired baseline measures. Further, the use of DBMs to generate an objective stressor reactivity score is…
This study has been transitioned to CTIS with ID 2023-503793-20-00 check the CTIS register for the current data. The main purpose of this study is to learn whether asundexian works better than placebo at reducing ischemic strokes in participants who…
In Part 1 we will investigate and compare to what extent RO6868847 is absorbed, distributed, metabolized, and eliminated from the body of 2 different types of tablet composition. This is done to see if both tablet compositions deliver the study…
To assess whether procedures and techniques used to derive AKT-DC out of lymph node material influences the quality and number of the AKT-DC end-product.
To assess the intensity of pulmonary inflammation as reflected by 18F-FDG-PET/CT in the first week of ICU admission and relate this to outcome (ICU mortality, VFD-28).
This research aims to generate knowledge about the sexual experience of clients with an SMI. Possibly the acquired knowledge can be used to create awareness among care providers. The ultimate wish is to adapt the treatment to the sexual experience…
The aim is to obtain sufficient data about aortic hemodynamics and motion in MFS patients in different disease stages (e.g. native aorta, after conventional surgery and after PEARS procedure) and while receiving different medical treatments, to…
The aim of the current project is to test the clinical and cost-effectiveness of GST for patients with an ED (i.e., anorexia nervosa, bulimia nervosa, other specified), that are not likely to benefit from CBT-E. The study will focus on those…
The primary objective of the study is to demonstrate the specific involvement of the cerebellum in reversal learning. The secondary objective is to investigate whether the behavioural effects of cerebellar cTBS on reversal learning are moderated by…
This study is designed as a single-center diagnostic accuracy study. The duration of the study is 2 years. To introduce tissue sensing during the stereotactic VABB, we developed an optical introducer with DRS fibers that can be integrated with the…
The primary objectives of this study are to assess the safety and estimate the radiation dose of the radioligand [18F]FB610, and to assess the optimal kinetic model for quantification of the tracer uptake. Secondary objectives are to determine…
This study has been transitioned to CTIS with ID 2024-518855-43-00 check the CTIS register for the current data. Primary objective: To evaluate the effect of SGLT2 inhibition with dapagliflozin 10 mg on serum magnesium in diabetic and non-diabetic…
Primary objectives: To determine the effects of combined isocaloric TRE and meal timing on insulin sensitivity.Secondary objectives: To determine the effects of combined isocaloric time-restricted eating and meal timing on hepatic fat content, de…
To investigate the safety and tolerability of DNL919To characterize the serum PK of DNL919
This study will evaluate the efficacy and safety of multiple therapies that are selected using somatic alterations and potential predictive biomarkers identified via NGS assays in patients with solid tumors.
Primary Objective: The main goal of this study is to provide evidence that steering saccharolytic/proteolytic fermentation by a specific indigestible fibre mixture supplemented against the background of a high-protein diet optimizes beneficial and…
This study has been transitioned to CTIS with ID 2023-506824-96-00 check the CTIS register for the current data. • safety and tolerability from baseline to week 64 in participants with hATTR or wtATTR cardiomyopathyPrimary • To compare the effect of…
The primary objective of this study is to evaluate the efficacy of endoscopic sutured gastroplasty (ESG) with the endomina device (EndoTools Therapeutics S.A.) in combination with optimal lifestyle measures on glycemic control, in obese patients…