3434 results
The purpose of this study is to explore the efficacy and safety of LTP001 in participants with WHO Group 1 pulmonary hypertension (PH), also referred to as Pulmonary Arterial Hypertension (PAH).This proof of concept study will be executed as the…
Therefore, this study aims to improve the understanding of the physiological effect of VNS on intestinal permeability, intestinal microbiota, immunological parameters in blood and breath in drug resistant epilepsy (DRE) patients. Additionally, this…
Primary objective:To investigate the dose - (clinical) response relationship and therapeutic window of biologics in the treatment of CRSwNP.Secondary objectives:- To investigate the effect of biologics on the sensibilisation pattern of specific IgE…
To evaluate plaque burden and characteristics in early-treated FH patients and to compare coronary plaque burden and characteristics between early- and late-treated FH patients as well as with non-FH controls.
This study has multiple purposes:Primary objective:1: to investigate whether it is possible to identify the small mimic muscles independently of each other and to determine the exact position of the origin and insertion of the mimic muscles on 7…
Primary:- To evaluate the effect of suvratoxumab on reducing the incidence of nosocomial all-cause pneumonia.Secondary:- To evaluate the safety of a single IV dose of suvratoxumab.- To evaluate the effect of suvratoxumab on reducing the incidence of…
To compare health-related quality of life, specifically fatigue, in melanoma patients treated with immunotherapy who use or do not use a patient-centered mobile coaching and monitoring system (CAPABLE). We expect that by using the CAPABLE eHealth…
Primary Objective: To evaluate whether KDT application as the KetoEasy meal plan induces ketosis and leads to seizure reduction in children 2-12 years with refractory epilepsy.Secondary Objective(s): To evaluate-Feasibility: application in daily…
Gain insight into the process through which suicidal thoughts lead to an attempt, and into the factors, considerations and preparations that play a role in this process
Primary Objective:- To investigate the association between temporal evolutions of blood biomarkers and clinical adverse events, in order to produce a dynamic, individual, and accurate prediction model for patients with HFpEFSecondary Objective(s):-…
The sponsor is developing a biological product (DRL_AB) similar to the approved medicine Orencia®. As part of medical-scientific studies to confirm the similarity of the biological products, the Sponsor wants to compare DRL_AB with EU-approved…
Primary Objective: Examine the accuracy of generated temperature values with three devices (Exergen, Braun and Genius) in concordance to rectal temperature in patients admitted to the Emergency Department (ED). Secondary Objective: Recommend the…
In this study we will investigate how quickly and to what extent ganaplacide is absorbed, transported, and eliminated from the body. Ganaplacide will be radioactively labelled with carbon-14 (14C). In this way, ganaplacide can be traced in blood,…
This study has been transitioned to CTIS with ID 2023-505645-12-00 check the CTIS register for the current data. Main objective: To evaluate the efficacy of BIIB122 225 mg compared with placebo.Secondary objective: To evaluate the efficacy, safety…
To investigate the effect of Bifidobacterium lactis CECT 8145 BPL1® on the seroconversion rate after influenza vaccination in healthy adults, compared to placebo treatment.
To examine the impact of medication induced systolic BP (SBP) reductions >=10 mmHg, while reaching a treatment target of <=140 mmHg, on cerebral blood flow (CBF) in frail elderly with untreated or uncontrolled systolic hypertension at…
This observational cohort study aims1. To identify subgroups of patients with hand and/or knee OA based on patient and disease related characteristics2. To identify subgroups of patients with hand and/or knee OA based on disease progression3. To…
The aim of the current research project is to test the assumptions of these two models by comparing the cognitive performance of individuals with DD on several tasks (e.g., memory processing, emotion perception) with patients with trauma-related…
Assess the potential efficay of L-serine dietary supplementation in patients children with a GRIN2B LoS mutation.
• To evaluate the safety and tolerability of THB001 in cold induced chronic urticaria patients