3434 results
What is the clinical- and cost-effectiveness of early low-dose oral immunotherapy aimed at long-term tolerance induction in children under the age of 30 months with an established food allergy compared to routine care?What is the effect of early low…
Evaluate the antitumor activity of nemvaleukin alfa (*nemvaleukin*, ALKS 4230) in combination with pembrolizumab as compared with chemotherapy in patients with platinum-resistant ovarian cancerSecondary Objectives:Evaluate the antitumor activity of…
Primary objective: The primary objective of the study is to evaluate the clinical efficacy of ISIS 721744 in patients with hereditary angioedema (HAE).Secondary objective: Evaluate the effects of ISIS 721744 on the quality and pattern of HAE attacks…
The aim of this study is to demonstrate that accurate brain stimulation is possible in anatomical location and timing.
The goal of this study is to characterize the natural history of STGD1 patients with the appropriate genotype for AON therapy and to identify the best clinical outcomes to measure therapeutic efficacy in clinical trials following completion of this…
The primary objective of the study is to evaluate the post-market safety and BMD improvement of AGN1 LOEP in patients with osteoporosis in at least one hip. The secondary objective is to evaluate the post-market functional measures of clinical…
The primary objective of this study is to describe and to quantify the change in cardiac mechanoenergetics, expressed by PVL monitoring (reflected by the parameters stroke work, potential energy and pressure-volume area), in patients undergoing…
The objective of this study is to investigate the effect of VR on post-operative pain and anxiety management in cardiac surgery patients undergoing a coronary artery bypass grafting (CABG) procedure.
This study has been transitioned to CTIS with ID 2022-502539-21-00 check the CTIS register for the current data. The purpose of this study is to determine the effect of nipocalimab on total serum immunoglobulin G (IgG) in pediatric participants 2 to…
The primary objective of the second part of the study, which is the focus of this application, is to perform a comparative analysis of the cognitive profile and MRI outcomes of DMD/BMD patients.
We aim to identify the utility of blood-based biomarkers for AD. Our first objective is to determine percent agreement between plasma biomarkers and clinical diagnosis set in a memory clinic. In summary: testing the agreement between plasma…
Primary objective: in this study, we want to investigate the performance of FH identification with a new approach using existing clinical laboratory data in which patients with severe hypercholesterolemia (LDL-C > 99.5th percentile for age…
The primary objective is to evaluate longitudinal developmental changes in brain structure in patients aged 6-18 years with SCD. The secondary objective is to analyze the longitudinal relations between biomarkers, demographic characteristics, brain…
The general aim is to identify the relevance and feasibility of a cost-effectiveness study on exercise therapy in patients with early stage knee OA1. What is the feasibility, in terms of percentage of eligible patients recruited, for GPs to recruit…
1. Are the results of the skin prick test (SPT) performed with homemade extracts and the prick-to-prick test (PTP) with fruit and vegetables comparable?2. Is there a difference in sensitivity and/or specificity between the SPT and PTP with fruit and…
Zie het onderzoeksprotocol 2: "Objectives".
To obtain an estimate of the prevalence of chlamydia and gonorrhoea among men and women aged 16.5 to 34 years.
Part A:The primary objective is to test the efficacy of the Myosuit, a soft exosuit, for increasing daily life gait performance in the home and community setting in people with iSCI. Secondary, the efficacy of the Myosuit program on gait capacity…
The objective is to identify which eye movement features are sensitive biomarkers for FTD. To answer this question, we will assess which eye movement features dissociate best between healthy controls, patients with FTD (familial and non-familial),…
To assess the effects of additional education in combination with more frequent follow up and patient reminders on adherence to treatment in adult EoE patients.