3434 results
To evaluate the performance of a *genotype first approach* (WES-based panel analysis) in diagnostics of genetic predisposition in children with cancer or neoplasms, compared to the current *phenotype first approach* (standard of care). In particular…
The primary objective of the study is to evaluate the progression free survival of patients when these are treated with ramucirumab and cyclophosphamide and vinorelbine, in comparison to treatment without ramucirumab.The secondary objectives of the…
This study has been transitioned to CTIS with ID 2024-510579-40-00 check the CTIS register for the current data. PRIMARY OBJECTIVES*Phase 1 Dose Finding Studies:-To determine the recommended phase II dose (RP2D) of new systemic therapy regimens. *…
The goals of this study are to evaluate the union rate, patient satisfaction and functional results of the Anser Clavicle Pin in a larger cohort then approved in the study, Anser; A novel intramedullary device for fixation of midshaft clavicle…
The current study is designed to collect viable growth plate tissue of tall statured individuals that undergo percutaneous epiphysiodesis (PE). With this collected biomaterial we will be able to characterize dynamic changes in growth plate…
Estimate key transmission parameters of SARS-CoV-2 in Europe from observing within household virus spread and seroconversion of household members, and to characterize the views and experiences of households regarding perceptions, practices regarding…
This study has been transitioned to CTIS with ID 2024-511492-15-00 check the CTIS register for the current data. Part 1:to evaluate the safety and tolerability of 2 doses (100 milligrams/kilogram [mg/kg] and 200 mg/kg) of eteplirsen in approximately…
The central question of this study is *What is the effect of supplementation of regular therapy with 8 weeks of HR after a first, acute, proximal DVT of the lower extremity on objective aspects of thrombus resolution which are associated with the…
In this study we will compare the (cost)- effectiveness of psychodynamic group therapy (PG) with schema-focused group therapy (SFGT) and group schema therapy (GST). The group formats differ both in amount of sessions (resp. 80, 60 and 30 sessions)…
This study has been transitioned to CTIS with ID 2024-514888-25-00 check the CTIS register for the current data. Objective: to provide proof of concept for the inhibition of HBx mediated cccDNA transcription by terbinafine, both as monotherapy and…
The FURTHER study aims to evaluate the effectiveness and cost-effectiveness of MR-HIFU (alone or in combination with EBRT) compared to EBRT alone, the standard-of-care, as a palliative treatment option to relieve CIBP.
Primary ObjectiveTo assess the treatment efficacy vs placebo of repeated low doses (20 µg) of LSD for six weeks in adult patients with ADHD measured by Adult Attention Deficit Investigator Symptom Rating Scale (AISRS).Secondary Objectives1. To…
To assess the effect of dupilumab on sleep, to evaluate the effect of dupilumab on additional patient reported sleep outcomes, on objective sleep assessment, asthma symptoms, long function and the safety of dupilumab.
This study has been transitioned to CTIS with ID 2024-512860-75-00 check the CTIS register for the current data. The aim of this feasibility study is to validate pre-treatment [89Zr]-bevacizumab PET/CT as an imaging biomarker for prediction of…
Primary Objective: • To determine the prevalence of NHR and BHR and determine the relationship between them in patients with chronic allergic and non-allergic rhinitis and compare with controls.Secondary Objective(s): • To determine differences in…
PrimaryThe primary objective for Part A of the study is to assess the pharmacokinetics (PK) of evinacumab in pediatric patients with homozygous familial hypercholesterolemia (HoFH).The primary objective for Part B of the study is to demonstrate a…
The primary objective of the study as a whole (part A-C) is to assess the PK and safety of buccal apomorphine relative to registered apomorphine formulations (subcutaneous, sublingual). Secondary objectives are the characterization of the PK-AE…
To investigate the feasibility of using 18F-PSMA PET-CT as a tumor-specific molecular imaging in PC, thus allowing for improved detection, therapy selection, and therapy response assessment.
To assess achieved immunity against COVID-19 across the different age groups in The Netherlands by testing a representative part of the Dutch population for the presence of SARS-Cov-2 specific antibodies in serum
To evaluate whether Fluorescence In Situ Hybridization (FISH) on blood cells can distinguish patients with QFS from controls with no evidence of past Coxiella exposure and individuals with past asymptomatic C. burnetii infection.