3434 results
The main aim of this study is to improve knowledge on the hemodynamic burden of labour in women with cardiac disease and women without cardiac disease, by examining CO trajectory through the full course of labour. Therefore, we specified the…
This study has been transitioned to CTIS with ID 2023-508129-28-00 check the CTIS register for the current data. The primary objective of this study is to characterize the pharmacokinetic (PK) profile of asciminib in pediatric patients, with the…
The current proposal aims to investigate the patellar tracking in patients receiving Journey II BCS total knee arthroplasty before and one year after surgery, positioned with the CORI instrumentation. The hypothesis is that less change in patella…
To evaluate the efficacy and safety of pamrevlumab versus placebo in combination with systemic corticosteroids in subjects with non-ambulatory Duchenne muscular dystrophy (age 12 years and older).
Alveolar cleft repair using osteoinductive ceramics in children with unilateral cleft lip and palate
To provide for evidence that calcium phosphate based scaffolds generate equal amounts of residual bone volume compared to the use of autologous bone grafts in unilateral alveolar cleft grafting. A secondary objective is to prove that calcium…
This study has been transitioned to CTIS with ID 2024-515669-32-00 check the CTIS register for the current data. The purpose of this study is to demonstrate superiority of macitentan 75 milligrams (mg) in prolonging the time to the first clinical…
Primary Objective: Assess if the structure, composition and/or barrier function of the biliary HCO3- umbrella is intrinsically altered in cholangioids and liver biopsies derived from fibrosing cholangiopathy subjects compared to non-fibrosing…
This study has been transitioned to CTIS with ID 2023-507230-24-00 check the CTIS register for the current data. To assess the feasibility of preserving fertility in women with 2018 FIGO stage IB2 cervical cancer with lesions measuring >2 cm…
This study has been transitioned to CTIS with ID 2024-515569-32-00 check the CTIS register for the current data. To study the safety and efficacy of mitapivat in the treatment of adult subjects with sickle cell disease.
The aim of the trial is to improve efficacy of nivolumab in patients with relapsed or refractory HL previously treated with an anti-PD1 antibody. Primary objective of the trial is to show efficacy of the experimental treatment strategy.Secondary…
To examine the PVS domain, and in particular reward circuits and behaviour, in large genetically informative cohorts comprising 500 individuals (including 125 SCZ patients, 125 BP patients, 125 relatives and 125 controls) already ascertained in the…
The aim of this study will be to evaluate the applicability of using CCE in the Dutch colorectal cancer screening programme in participants with positive FIT outcomes who have contra-indications for subsequent colonoscopy, who have a prior…
The aim of this prospective 2-year follow-up study is to investigate the predictive capacity of the CAR-test for development of cardiovascular events after elective AAA repair in comparison to the SMART risk score. Secondary objectives are to…
This study has been transitioned to CTIS with ID 2023-507933-12-00 check the CTIS register for the current data. MAIN OBJECTIVES:- To compare the efficacy of Dato-DXd in combination with pembrolizumab versus pembrolizumab alone, as measured by…
This study aims to investigate the effect of maternal diet and ethnicity on breast milk composition.In addition, we look at possible differences in the intestinal flora and the health of the infant based on the composition of the breast milk and…
This study has been transitioned to CTIS with ID 2024-516379-34-00 check the CTIS register for the current data. Objectives:To compare the efficacy of Atropine 0.05% to Atropine 0.5% treatment in European children with progressive myopia, and to…
The primary aim is to evaluate the effectiveness of ACT your way, by comparing ACT your way to treatment as usual (TAU) in TAY. The secondary aim is to evaluate the cost-effectiveness of ACT your way, by comparing ACT your way to TAU in TAY. The…
The main objectives of this project are to increase our knowledge of factors playing a role in the maintenance of body image concerns in eating disorder patients. More specifically, we will examine the involvement of disgust-based avoidance of…
This study has been transitioned to CTIS with ID 2023-505974-14-00 check the CTIS register for the current data. Main objective:English To evaluate the longer-term safety of ocrelizumab in participants diagnosed with MS who were previously enrolled…
Primary Objectives:• To determine the safety of ELA026 administered IV and SC to participants with sHLH.• To identify the RP3D and schedule for ELA026.Secondary Objectives:• To characterize the pharmacokinetic (PK) profile of ELA026 administered IV…