3434 results
The aim of this study is to explore differences in expression of Rac1 and pSTAT3 in leucocytes of therapy-naïve IBD patients, IBD patients on immune suppressive therapy and healthy controls.
To determine the influence of darolutamide on the pharmacokinetics of cabazitaxel compared to cabazitaxel alone in mCRPC patients.
The primary objective is to evaluate whether the concentration of six biomarkers (proteins) in SDH are related to the time of incidence of TBI. The secondary objective is to evaluate whether the fractions of the Hb-derivatives in SDH are related to…
Primary:Long-term safety of nivolumab in participants on treatment and in follow upExploratory:To follow participants who have completed therapy and are in or have completed follow-up on a parent study investigating nivolumab or nivolumab…
Primary Objective: To study in detail whether a 12-week home based personalized IMT training scheme using the POWERbreathe KHP2 in DM1 patients could result in improvement of maximum inspiratory pressure (PImax) and endurance capacity. We postulate…
In the present study we aim to assess the effectiveness of a Dutch version of the parenting training based on DBT for mothers with BPD, with children aged 0-8 years (developed by Renneberg and Rosenbach, 2016) on (1) parenting behaviour, (2)…
The main objectives are:• To assess canagliflozin target (i.e. receptor) specific binding in vivo• To assess receptor occupancy of canagliflozin in vivo• To determine optimal scanning time in vivoTo explore the relationship between canagliflozin…
Study aimsThe aim of the current study is to assess the effect of a nasal airway stent (Nastent R) as a treatment modality in patients with snoring and/or OSA. Hypothesis Nastent R, a distally perforated soft silicon nasal tube, is a mechanical…
To characterize the presence of anti-Covid-19 IgM and anti-Covid-19 IgG in volunteering employees of the Department of Gastroenterology and Hepatology of the Erasmus MC.
The aim of this prospective randomized, double blind placebo-controlled trial study is to evaluate the analgesic effects of preoperative PECS-II block in addition to general anaesthesia for breast conserving surgery compared to a placebo block. Our…
The potential use of 99mTechnetium (99mTc)-based PSMA-radioguided surgery (99mTc-PSMA-RGS) for salvage lymphadenectomy for PC.
The main objectives of this study are:1. To identify the role of conformational changes of ADAMTS13 on hyperfibrino(geno)lysis in in vitro coagulation tests (primary)2. To identify the role of plasmin on ADAMTS13 conformation on in vitro coagulation…
In this explorative-study, we aim to investigate the relation between cDPP3 release kinetics and clinical outcome parameters in OHCA patients after ICU admission. This could lead to the identification of a new predictive marker, a potential…
The study*s main objective is to measure blood micro- and macronutrient and amino acid levels in adults with PKU on a protein substitute and compare with age- and sex-matched non-PKU comparison subjects.
Whether disrupting reconsolidation by a noradrenergic β-blocker provides long-term relief of PTSD symptoms in traumatized healthcare workers.
The primary objective of this randomized controlled trial is to investigate the effect of the VR-TRAC on aggression in a prison-based population.
1. to test differences in movement patterns during a standardized lifting task and gait between patients with chronic low back pain with high central sensitization (CS+), low back pain with low/moderate central sensitization (CS-) and healthy…
(I) Investigating the role of the cholinergic system and CBGTC-loop in the pathophysiology of CD, related to both motor and NMS; (II) Finding a biomarker for DBS efficacy in CD, including motor and NMS.
To evaluate the validity of grip work and self-perceived fatigue measured with the eforto® system for monitoring hip fracture recovery and insight in resilience.
The primary study endpoint is the respiratory exchange ratio (RER) during the night. The secondary objectives are to examine how differentially timed exercise affects 1) 24h energy and substrate metabolism and 2) the immune response based on…