3434 results
Objectives: 1) Assess neural and cognitive biomarkers (through eye-tracking, EEG/ERP and cognitive measures) in a community sample of infants at heightened non-familial risk for ASD and in age and gender matched low-risk controls. The HR group is…
1. To investigate the feasibility to perform advanced echocardiographic measurements2. To describe the incidence and variation of cardiac damage during and shortly after treatment using detailed advanced echocardiographic measurements and ECG at…
a. Primary Objective: To examine the (barriers and facilitators of) the current use of SDM in doctor-patient communication, we will explore the communication practices (verbal and nonverbal) used by physicians and patients.Research questions:1) What…
The purpose of this study is compare a tablet formulation of PXL770 to the capsule formulation of PXL770. It will be investigated how quickly and to what extent PXL770 in each formulation is absorbed and eliminated from the body. To limit the…
Primary objectives: - To test the hypothesis that a relationship between mitochondrial oxygenation and serum lactate existsSecondary objectives:- To provide data for estimating the number of patients needed for a clinical trial to prove the above…
Translation of [18F]-MC22518 to the clinic to measure P-gp function in healthy volunteers.
Primary objective: to acquire patient data required to optimize/train a method to generate synthetic CT scans from MRI scans and to determine the suitability of the synthetic CT scans for radiotherapy treatment planning.Secondary objective: To…
To explore the effect of single versus repeated preconditioning on circulating blood factors (i.e. metabolomics analysis) as a likely mechanism in patients with cSVD. Secondly, we explore whether the effects of single versus repeated preconditioning…
In different stages of HCM:- To measure myocardial fatty acid oxidation, uptake and esterification- To measure myocardial glucose uptake en oxidation- To measure myocardial perfusion- To measure myocardial function- To measure volume parameters of…
It is known that physical examination and visual inspection of haematomas is unreliable and therefore there is a need for a reliable and validated method. This to be able to create a timeline which can be used to identify or exclude potential…
The first objective is to validate novel digital biomarkers for disease progression in de novo Parkinson*s disease patients. The biomarkers can eventually serve as a primary clinical endpoint in additional future clinical studies. As part of this…
The purpose of this study is to investigate how safe the new compound OMS906 is and how well it is tolerated when it is administered to healthy volunteers. OMS906 has not been administered to humans before. It has been previously tested in the…
- To evaluate the single-dose PK and pivotal bioequivalence of 3 compounds darunavir (DRV) 675 mg, FTC 200 mg, and tenofovir alafenamide (TAF) 10 mg in the presence of cobicistat (COBI)150 mg when administered as an fixed-dose combination (FDC) (D/C…
Main objective of the trial is to determine the effect of individualizing the immunosuppressive therapy based on baseline immune-risk stratification according to 2 new biomarkers (d-sp ELISPOT IFN-γ and donor/recipient HLA Eplet Mismatch), in a…
To investigate the interrelatedness between clonal hematopoiesis of indeterminate potential (CHIP) and trained immunity.
We aim to investigate the effectiveness of implementation of a TPS compared to standard of care (SOC) for patients at risk of developing CPSP, as measured by quality of recovery, incidence of CPSP and opioid consumption.
This study has been transitioned to CTIS with ID 2024-511530-12-01 check the CTIS register for the current data. We hypothesize that treatment of RA can be individualized by taking into account the presence of autoantibodies and quick response to…
- To compare the pharmacokinetics (PK) of glepaglutide after a single subcutaneous (SC) administration by vial/syringe and by autoinjector.- To evaluate the safety and tolerability of glepaglutide following SC dosing in healthy subjects.
A stepped-wedge cluster randomized trial with a clear aim to demonstrate the clinical outcomes, the mechanistical effect and the cost efficiency of prehabilitation across a wide range of patients, diseases and procedures.
We aim to demonstrate that robot-assisted laparoscopic radical hysterectomy is non-inferior to conventional laparotomy in recurrence free survival of patients with early stage cervical cancer (stage 1B1, 1B2 and 2A1).