3434 results
1) to study the effects of 4 weeks of HIIT compared to 4 weeks of CAE on motor and non-motor aspects of PD; 2) to investigate the association between blood biomarkers for neuroplasticity / neurodegeneration and motor and non-motor performance for…
Primary:To determine the efficacy of AG10 in the treatment of subjects with symptomatic transthyretin amyloid polyneuropathy (ATTR-PN) by evaluating the difference between the AG10 and placebo groups in Modified Neuropathy Impairment Score + 7 (mNIS…
To assess the accuracy of the screw placements after using a surgical guide in patients operated for intra-articular tibial fractures.
In this explorative study, we aim to:• Analyze neoantigens expressed on different tumors of CMMR-D patients, to identify possible target antigens for DC vaccination studies.• Investigate the presence of pre-existing immune responses against…
The objectives of STIMO-2 are to demonstrate the safety and feasibility and to obtain preliminary evidence on the effectiveness of mobility rehabilitation facilitated by TESS to improve neurological recovery when this intervention is delivered in…
Accuracy of early detection of recurrent/metastatic disease in HNSCC patients treated for cure, and the median and range of time intervals between relapse and presence of ctDNA in plasma and oral rinses as well as TEPs.
The primary objective is to investigate the efficacy of a single intradiscal injection of STA363 into one or two IVDs as compared to placebo by the following primary efficacy endpoint:* Change from baseline at Month 6 in mean pain intensity measured…
Primary Objective:1. The primary objective is to investigate the level of agreement between scoring the presence of IPH on MR images acquired with MP-RAGE (conventional sequence) with scoring IPH on the multicontrast sequences. The level of…
The main objective of this study is to create and validate subject-specific models of the human neuromuscular system capable of estimating neuro-mechanical activity in vivo in healthy, post-stroke and SCI individuals. In addition, we want to prove…
To investigate the effect of a dietary intervention based on a WFPD on serum uric acid levels, gout disease activity and cardiovascular risk in patients with gout.
The current project aims to implement male-female specific insights into aortic root and ascending aorta characteristics into clinical practice, allowing better identification of high risk Thoracic Aortic Aneurysm (TAA) patients and better timing of…
The main objective of this pilot study is to evaluate the effect of motion mitigation with BiPAP or CPAP on tumor motion during the course of radiotherapy in patients with intra-thoracic tumors.
The primary objective is to assess the safety and efficacy of the Early@home telemedicine system that relocates hospital care for patients recovering of COVID-19 to the home situation. The secondary objective is to assess the impact of this…
Primary objective: to examine the association between the size of intrinsic foot muscles and gait biomechanics and balance in older adults.
The primary objectives of this study are:· To assess the time to first exacerbation of COPD, measured from the time of randomization The secondary objectives of this study are:· To evaluate the improvement of quality of life by Saint George*s…
Validate and improve the new experimental algorithm.
The main objective of this study is to assess efficacy of the closed loop system in patients after total pancreatectomy. Secondary objectives are to assess the safety of the closed loop system; to determine the time that the control algorithm is…
Main objective:*To evaluate the dose-response relationship of 2 doses of etrasimod versus placebo as induction therapy in subjects with moderately to severely active Crohn's disease (CD).*To select an oral etrasimod dose, based on efficacy and…
The objective of this study is to demonstrate that use of the Sentinel® Cerebral Protection System significantly reduces the risk of periproceduralstroke (*72 hours) after transcatheter aortic valve replacement (TAVR).
The objective of the current study is to eveluate whether EMDR is effective in reducing PD symptoms.