341 results
To compare the oncologic outcomes of PCa patients with an estimated risk of lymph node invasion of 5-20% according to the Briganti nomogram without metastases on PSMA PET/CT undergoing a radical prostatectomy (RP) with or without an ePLND.
Gain a better fundamental understanding of the functioning of the human immune system.Our research focuses on the mechanisms involved in 2 aspects: 1. The induction of Tregs (and inhibition of Th2 cell polarization) by exposing DCs to certain…
This study has been transitioned to CTIS with ID 2024-511321-54-00 check the CTIS register for the current data. Primary objective:To assess the efficacy of reduced dose thrombolytic therapy in patients with acute intermediate-high risk pulmonary…
To contribute to building a sound scientific basis for the regulatory EU institution to set-up occupational exposure limits and related biological limit values, as well as reference values for the general population and to study the impact of the…
The study hypothesis is that adjunctive antibiotic therapy will improve clinical response to standard of care (SOC) induction therapy in a subgroup of CD patients with a relapse-associated microbiome profile.
We expect to find that e-liquids with nicotine salts taste milder and are easier to inhale than e-liquids with free-base nicotine. More specifically, we hypothesize that e-liquids with nicotine salts, in comparison to free-base e-liquids: 1. are…
The clinical efficacy of CFTR modulating drugs is limited, some patients respond, while others do not or have side effects. The inter-individual variability (IIV) in the PK seems large, and therefore we hypothesize that we might be over- or…
Multifactorial approach of aftercare, focussing on fear reduction for (recurrent) dislocation, is more effective than the current standard of aftercare for patients who underwent arthroscopic bankart repair without significant bone loss
Emerging techniques measuring oxidative APAP metabolites and microRNA-122 (miR-122) could make it possible to detect paracetamol induced liver injury earlier and more precisely than currently used paracetamol plasma concentrations and clinical…
The aim of the study is to investigate the effect of magnetic resonance (MR) based online adaptive radiotherapy (RT) for treatment of low to intermediate risk localized prostate carcinoma (PCa) on the radiotherapy dose on the prostate and organs at…
1. We hypothesize that the ingestion of 30 g of collagen peptides and 30 g of free amino acids (matching the profile of collagen peptides) will result in greater myofibrillar and connective tissue protein synthesis rates in skeletal muscle tissue at…
It is hypothesized that measurement of CO, SV and LVEF with the Lumify/DIA system corresponds with CO, SV and LVEF measurements with conventional non-automated echocardiography.
We hypothesize that CBFV measurement in the ICA and pACA using Doppler CUS will become a monitoring technique to guide optimizing cerebral perfusion in the perioperative phase. Furthermore, HFR Doppler CUS will provide additional quantitative…
We hypothesize that the MACE and mortality rates will be very low, due to mild or absent coronary disease on the CCTA and the short follow-up duration.
It is hypothesized that CATs and PROMIS short-forms have higher measurement precision and smaller measurement error (better detectable change) as compared to currently used PROMs.
We hypothesize that treatment with Tapentadol will reduce the development of chronic postoperative pain by enhancing or maintaining CPM responses and possibly reducing central sensitization. We hypothesize that a 4-week treatment with Tapentadol…
The aim of our survey is to uncover the gap between the demand and supply of simulation based education, with a difference in perception between residents and their educational/clinical supervisors.
Timing and dosing of BH4 potentially impacts Phe and Tyr variation in PKU patients treated with BH4 and thus potentially impacts outcome.
Family participation in physiotherapy related tasks is feasible and acceptable