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Exercise therapy in people with early-stage knee osteoarthritis: a feasibility study

The general aim is to identify the relevance and feasibility of a cost-effectiveness study on exercise therapy in patients with early stage knee OA1. What is the feasibility, in terms of percentage of eligible patients recruited, for GPs to recruit…

Prevalence Estimate Chlamydia And gonorrhoea Netherlands, second edition

To obtain an estimate of the prevalence of chlamydia and gonorrhoea among men and women aged 16.5 to 34 years.

Compensatory reading training for people with homonymous visual field defects

This project aims to determine the effectiveness of two reading interventions: Vistra and Rotated Reading. The effects will be investigated on the level of functions, activities and participation. A nuanced view will be provided as to which training…

Combined tomosynthesis and ultrasound breast imaging

Primary Objectives: 1) Is it feasible to implement plane-wave imaging in a combined DBT-US device to decrease scan time while preserving or improving image quality compared to conventional imaging? 2) How do DBT images compare obtained by DBT with a…

Study to evaluate the effects of intravenously administered LPS on the bone marrow immune cell compartment in healthy male volunteers

• To investigate the (early) effects of i.v. LPS challenge model on the bone marrow and whole-blood immune compartments, by: o evaluating the immune cell subtypes present within the myelo- and lymphopoiesis in the bone marrow niche before and after…

The RepEAT study: Individual differences in postprandial glucose responses and the relation with diet and phenotype

The primary objective of this study is to determine the variation in postprandial glucose responses to the same meals/food products and how this relates to the variation in postprandial glucose responses over a 9-week fully controlled dietary…

TOLERANCE: a 3 arm randomized study on healTh-related quality Of Life of EldeRly pAtients with advaNced soft tissue sarComa undergoing doxorubicin every three weeks or doxorubicin weekly or cyclophosphamide plus predniso(lo)ne treatment

Main objectiveThe primary objective of this study is to assess whether a higher HRQoL, in terms of impact of the disease and its treatment on physical and role functioning, is achieved with metronomic schedules of doxorubicin or cyclophosphamide…

Virtual Reality for Pain Relief in the Emergency Room for Reduction of Fractures and Joint Dislocations

Primary Objective: Can VR reduce periprocedural and postprocedural pain during reduction of fractures and joint dislocations in the ED? Secondary Objectives: What are the effects of VR on peri-procedural anxiety?Does the level of peri-procedural…

A First in Human, Phase 1, Randomized, Double-blind, Placebo-controlled, Single Ascending Total Daily Dose Study to Assess Safety, Tolerability, and Pharmacokinetics of Single and Multiple Intravenous Infusion of OMN6 in Healthy Subjects

Primary objective: To evaluate the safety and tolerability of single ascending i.v. doses of OMN6 in healthy young and elderly adult subjects.Secondary objective: To evaluate OMN6 PK in plasma following single ascending i.v. doses in healthy young…

A Prospective, Multicenter, Open Label, Single Arm, Study to Assess the Safety & Performance of the Harmony Aortic Stimulation System (HASS) for the Treatment of Heart Failure

Evaluate the performance and safety of HASS 200 (HARMONY AORTIC STIMULATION SYSTEM) in treatment of heart failure subjects.

The effect of ingesting a whey and collagen protein blend on myofibrillar and connective tissue protein synthesis rates at rest and during recovery from exercise

To assess the impact of the combined ingestion of whey and collagen protein on myofibrillar and connective tissue protein synthesis rates in muscle tissue obtained at rest and during recovery from exercise in vivo in humans.

A phase 1, randomized, double-blind, placebo-controlled, multiple dose platform study investigating the immunopharmacology of EDP1815 and EDP2939

Primary• To evaluate the effect of EDP1815 (same dose using EC1 and EC2 capsules) and EDP2939 (two dose levels using EC2 capsules) on the immune system.Secondary• To evaluate the effect of EDP1815 (same dose using EC1 and EC2 capsules) and EDP2939 (…

Establishing immunogenicity and safety of needle-free intradermal delivery by nanoporous ceramic skin patch of mRNA SARS-CoV-2 vaccine as a revaccination strategy in healthy volunteers

Primary objective - to describe immunogenicity and safety in healthy volunteers of the intradermal dermal delivery of a single fractional dose of 20µg mRNA-1273 LNP vaccine (Spikevax, Moderna) more than 3 months after primary vaccination with…

Transcranial ultrasonic stimulation of the primary motor cortex

To confirm our previous findings that both TUS and auditory cuing decreases MEP amplitude in an independent sample using a more efficient design. Reducing the number of principal conditions will benefit data quality and allow for better estimation…

A Multicenter, Phase 1/1b Open-Label, Dose-Escalation Study of ABBV-399, an Antibody Drug Conjugate, in Subjects with Advanced Solid Tumors

The purpose of this study is to evaluate how safe telisotuzumab vedotin is and how telisotuzumab vedotin is tolerated as monotherapy and in combination with osimertinib.

Relative bioavailability study to investigate a potential interaction between dolutegravir (DTG) and tenofovir alafenamide fumarate/emtricitabine (F/TAF) administered as paediatric tablet formulations.

Primary objectives:- To assess the relative bioavailability of TAF and TFV after a single-dose FTC/TAF 3x60/7.5 mg DT (reference TAF) compared to TAF and TFV after a single-dose FTC/TAF 3x 60/7.5mg DT in combination with a single dose of DTG 30mg as…

Polyp size measurement during real-time colonoscopy using the virtual scale function SCALE EYE: variability and systematic differences

1. To assess the variability (spread) and systematic differences in polyp size measurement between SCALE EYE and several other measurement techniques (without reference [i.e. 'carpenters eye'], opened snare (of known size) as reference,…

Feeling Hot 1: Investigating the influence of clothing and blankets on penile skin temperature during male sexual arousal

The objective of the Feeling Hot 1 study is to determine the change in penile skin temperature regarding the temperature increase and sensor response time during visually aroused erections when considering environmental influences of overnight…

Moving through Levels of Care. Maintaining functioning during older adults' transition to the nursing home, a pilot study.

The primary objectives of the pilot study are: 1. To determine a successful strategy for recruiting and following-up participants during their transition phase from home to a nursing home; 2. To determine the suitability of the study procedure; 3.…

The influence of having bariatric surgery on the pharmacokinetics, safety and efficacy of the novel non-nucleoside reverse transcriptase inhibitor doravirine (LABRADOR)

Primary objective: • To assess the pharmacokinetics of DOR in patients prior to and after BSSecondary objectives: • To assess the safety of DOR in patients prior to and after undergoing BS• To assess the viral response to DOR in patients prior to…