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A randomized, double-blind, placebo-controlled, multiple ascending dose study to evaluate safety, PK and the immunosuppressive effects of p38 MAPK inhibitor POLB 001 on the intradermal and intravenous LPS challenge response in healthy volunteers.

• To evaluate the effect of POLB 001 on inflammatory responses following an intradermal LPS challenge in healthy volunteers• To evaluate the effect of POLB 001 on inflammatory responses following an intravenous LPS challenge in healthy volunteers

Acute immunotoxicological effects of traffic-related micro- and nanoplastics in urban air.

The main objective is to study presence of MNPs in blood and short-term changes in blood leukocytes, inflammatory markers and the anti-oxidant defence system, in association with traffic-related microplastic exposure in healthy young adults.…

An open-label, mass balance study of 14C-JNJ-40411813 administered as a single oral dose in healthy male participants

The aim of this study is to investigate how quickly and to what extent JNJ-40411813 is absorbed, transported, and eliminated from the body. For this study, JNJ-40411813 is radioactively labelled with carbon-14 (14C). In this way JNJ-40411813 can be…

Fully Automated glycemic control with ultrarapid insulin in a bihormonal closed loop System in patients with Type 1 diabetes.

The main objective is to determine the efficacy of Lyumjev in the Inreda AP system. Secondary objectives are: to assess safety, differences in pharmacodynamics and differences in AP-related outcome measures.

The impact of passive heat treatment on glycaemic response during an oral glucose tolerance test in diabetic patients

To assess the acute impact of passive heat treatment on the post-prandial glycaemic response during an OGTT in T2DM patients.

Evaluation of adhesions formation using conventional third generation endometrial ablation with and without postoperative application of an intrauterine adhesion barrier film

Evaluate the formation of adhesions after third-generation endometrial ablation, with and without the intrauterine adhesion barrier

A randomized, double-blind, phase III study comparing NIS793 in combination with gemcitabine and nab-paclitaxel versus placebo combined with gemcitabine and nab-paclitaxel for first line treatment of metastatic pancreatic ductal adenocarcinoma (mPDAC)

The purpose of this study is to evaluate the efficacy and safety of NIS793 in combination with gemcitabine/nab-paclitaxel versus gemcitabine/nab-paclitaxel and placebo in first-line mPDAC.This study aims to explore whether blockade of Transforming…

Double-blind, placebo-controlled phase 1 trial of nizaracianine administered in three divided doses to healthy volunteers

Primary• To assess the safety and tolerability in healthy volunteers of nizaracianine administered IV in three divided dosesSecondary• To perform pharmacokinetic analyses of blood and urine• To determine if bolus injection of nizaracianine enables…

Individualisation of management with novel upfront therapy enzalutamide in newly diagnosed metastasized prostate cancer using (PSMA)PET/CT imaging

To assess the predictive value of early response measurements on PSMA-PET/CT for therapy success, defined as time to development of castration-resistant prostate cancer (CRPC), in order to personalize treatment choice.

A Phase 1 Study to Assess the Mass Balance, Absolute Bioavailability, and Pharmacokinetics of 14C-ASTX029 in Healthy Volunteers

Primary objectives:To identify and quantify the excretion pathways of oral ASTX029, including the mass balance and the excretions in urine and feces (Period 1).To determine the absolute oral bioavailability (F) of ASTX029 under fasting conditions (…

A Study to Evaluate the Safety, Tolerability, and Effects on NSAID-Induced Small Bowel Pathology of K-196 in Healthy Volunteers.

Primary:1. To characterize the safety and tolerability of multiple oral doses of K-196 alone and in combination with naproxen/omeprazole in healthy subjects.Secondary:1. To assess the effects of K-196 compared to placebo on the proportion of…

The effect of mealworm protein on muscle damage in active vital elderly

To investigate the impact of the daily consumption of a mealworm- and whey protein supplement on muscle damage upon physical exercise in vital active elderly.

Multicenter study of the performance of Fabian-PRICO for saturation targeting routine use in the NICU

Investigate whether, in a routine clinical environment across a number of centers, the fabian-PRICO can adequately maintain oxygen saturation, with minimal staff intervention.

The effect of Virtual Reality on pulmonary recovery and mobility in patients with blunt chest trauma.

Primary Objective:To investigate the effect of respiratory and physical exercises in VR on pulmonary recovery compared to the standard of care of patients suffering from blunt chest trauma.Secondary Objective(s):- To investigate if VRx can improve…

RESilience in Hip frActure Patients measured with the Eforto(R) measurement & monitoring system

To evaluate the validity of grip work and self-perceived fatigue measured with the eforto® system for monitoring hip fracture recovery and insight in resilience.

Distribution, dosimetry and imaging of [195mPt]cisplatin in cancer patients

Investigate the distribution, dosimetry and image quality of [195mPt]cisplatin in cancer patients