11 results on atopic dermatitis
Primary objectives • To characterize the histamine dose response on pruritus• To profile the response to intradermal histamine by:o Clinical measureso Biophysical measureso Imagingo Molecular and cellular responsesSecondary objective • Comparison to…
BIOMAP (Biomarkers in Atopic Dermatitis and Psoriasis) NL is part of the BIOMAP consortium, which is a EU-funded consortium through which various research projects will address three main unmet needs in AD and Pso with a broad impact on disease…
To determine the frequency and suppressive potential of skin resident regulatory T cells isolated from atopic dermatitis and psoriasis patients compared to healthy control subjects (the latter data will be obtained by co-workers at the Brigham and…
Investigate the role of CD8+ T cells in AD by:a. Isolation of T cells from the skin and determination of the percentage and phenotype of CD8+ T cells in both acute and chronic AD, using the APT as an in vivo induction model. Comparison with…
The major aim is to apply deep sequencing technology to obtain a detailed unbiased overview of the bacterial microbiome of human skin. This will be performed in healthy individuals, psoriasis patients and atopic dermatitis patients. Furthermore, we…
Primary Objective: 1) We want to investigate whether carriers of FLG-null mutations show higher responses to exposure to the skin irritant SLS than non-carriers.2) Furthermore, we want to investigate whether carriers of mutations in the genes coding…
Primary objectives• To evaluate complement activation after topical imiquimod challenge• To evaluate complement activation after local UV-B challenge
We aim to identify the predictive value of the candidate biomarkers suggested by the EAACI taskforce for response to AIT. Additionally, we aim to explore novel candidate biomarkers both for clinical follow up as well as contribute to unravelling the…
In vitro selection of microbiota that can be used in a subsequent trial with children with IMD. The selection will be made based on the cytokine profile and immune cell characterization after co-culture of PBMC*s with bacteria. Influence of human…
The goal of this study is to validate and interpret a new HRQOL instrument and to analyse commonly used outcome measurements (PGA, PtGA) in dermatology.
Primary Objective• To evaluate the local safety and tolerability of INM-755 cream following repeated once-daily topical applications for 14 consecutive days on wounded skin of healthy volunteers. Secondary Objectives• To evaluate the systemic safety…