20 results on atopic dermatitis
Primary objectives • To characterize the histamine dose response on pruritus• To profile the response to intradermal histamine by:o Clinical measureso Biophysical measureso Imagingo Molecular and cellular responsesSecondary objective • Comparison to…
The main study objective is to determine the time to, as well as number of exacerbations of atopic dermatitis in the study period between the study groups A and B.The secondary objectives are the differences in transepidermal water loss and Quality…
The main study objective is to determine the time to, as well as number of exacerbations of atopic dermatitis in the study period between the study groups A and B. The secondary objectives are the differences in transepidermal water loss and Quality…
To compare the clinical outcome of daily showering followed by immediate application of emollient to once weekly showering followed by immediate application of emollient, in children with mild to moderate AD. The primary outcome parameter will be…
We hypothezise that methotrexate and azathioprine will be equally effective for the treatment of severe atopic dermatitis.
The effectiveness and cost-effectiveness of treatment with systemic cyclosporine or dupilumab in children with moderate-to-severe atopic dermatitis is different for patients with low NMF (corresponding with filaggrine-gene mutation) versus children…
We hypothesize that atopiform dermatitis is a separate entity with specific characteristics, which needs recognition in order to be diagnosed and treated appropriately.
Primary objective: To establish the PK profile after multiple SC administrations of tralokinumab in children with moderate-to-severe AD.Secondairy objectives: - To assess the safety and tolerability of multiple SC administrations of tralokinumab in…
As NB-UVB is known to be effective in AD, the excimer laser appears to be a promising treatment for localized AD. We designed a randomized single blind within-patient controlled trial to investigate the efficacy of the excimer laser versus routine…
To compare the efficacy and safety of methotrexate versus azathioprine treatment in adult patients with chronic severe AD.
Isoleucine is an aminoacid showing in vitro efficacy in increasing keratinocytes to increase the production of Antimicrobial peptides (AMP)such as beta defensine. In AD there is a reduced production of AMP
A positive effect of the study product in preventing asthma like symptoms in infants at high risk for developing asthma later in childhood.
This is a set-up for a challenge pruritus model. We expect to initiate a local, reversible itch- response
Comparing the effectiveness and cost-effectiveness of narrowband ultraviolet B with optimal topical therapy (NB-UVB+OTT) versus OTT at 3 months in adult patients with atopic eczema (AE).
Daily showering followed by immediate application of emollient is better for the clinical outcome of mild to moderate AD in children, when compared to once weekly showering followed by immediate application of emollient.
Primary Objectives • To assess the pharmacodynamic effects of prednisolone on the IMQ-induced inflammatory response • To assess safety & tolerability of topical IMQ in combination with prednisolone Secondary Objectives • To explore…
The purpose of the study is to investigate to what extent GBR 830 is tolerated. It will also be investigated how quickly and to what extent GBR 830 is absorbed and eliminated from the body (this is called pharmacokinetics). In addition, the effect…
Our aim is to optimize treatment for patients with moderate to severe psoriasis by creating evidence for the optimal dose of MTX (on short- and long-term) with the largest disease reduction and the least side effects.
The primary objective of this study is to assess the efficacy and safety of non ablative and ablative fractional lasers in various pigment disorders.
Computerized decision support (CDSS) for tailoring prevention to the local circumstances using the guidelines of the Dutch college of general practitioners has impact on preventive activities in the primary care setting