De rol van het hormoon TSH in het immuunsysteem.

1. Have the capacity to understand and willingness to sign an informed consent form;

2. Have been medically treated for primary hypothyroidism for the last 6 months with only thyroxin substitution therapy;

3. Adequate treatment with thyroxine;

4. Have medically controlled disease;

5. T3 and T4 blood levels within the normal range for the past 6 months;

6. TSH within the normal range for the past 6 months;

7. TSH>20 mU/l at diagnosis;

8. Presence of anti TPO antibodies;

9. Age 20-45 years.

1. Uncontrolled hypothyroidism;

2. Presence of antibodies to the TSH receptor;

3. History of M. Graves or thyroiditis;

4. Presence of struma;

5. Enlarged tyroid gland measured with ultrasound;

6. Serious infections in the last 3 months;

7. Have current symptoms of cardiac disease;

8. Have current signs or symptoms of severe, progressive or uncontrolled renal, hepatic, hematologic,
gastrointestinal, endocrine, pulmonary, cardiac, neurologic, or cerebral disease;

9. Clinically relevant abnormal findings during routine physical examination, screening blood samples of
hematology, biochemistry, urinanalysis and/or known ECG abnormalities;

10. Alcohol abuse;

11. Known hematologic malignancy;

12. Known thyroid malignancy;

13. Other autoimmune disorders than hypothyroidism;

14. Thymectomy in the medical history;

15. T cell affecting co-medication.
Pregnancy