The hypothesis is that exogenous hormone administration (oral administration of estrogen and gestagen) starting immediately after successful hysteroscopic adhesiolysis, in patients with Asherman Syndrome reduces or prevents the incidence and…
ID
Bron
Verkorte titel
Aandoening
Asherman Syndrome
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Spontaneous recurrence of intra uterine adhesion
Achtergrond van het onderzoek
Evaluation of exogenous hormone administration (oral administration of estrogen and gestagen) starting immediately after successful hysteroscopic adhesiolysis, in patients with Asherman Syndrome (As) reduces or prevents the incidence and severity (ESGE score/classification) of spontaneous re-adhesions better then the endogen production of hormones. Secondly to evaluate the long term outcome of fertility, pregnancy and obstetrical outcome and chronical pelvic pain
Doel van het onderzoek
The hypothesis is that exogenous hormone administration (oral administration of estrogen and gestagen) starting immediately after successful hysteroscopic adhesiolysis, in patients with Asherman Syndrome reduces or prevents the incidence and severity (ESGE score/classification) of spontaneous recurrence of adhesion better then the endogen production of hormones.
Onderzoeksopzet
1 year, 3 years, 10 years
Onderzoeksproduct en/of interventie
exogenous hormone administration (oral administration of estrogen and gestagen) starting immediately after successful hysteroscopic adhesiolysis
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Consented patients with Asherman Syndrome (AS) who had a successful hysteroscopic adhesiolysis, defined as a restore of the normal uterine cavity, were eligible for inclusion. Patients with AS should be defined as patients with any diminishing of blood flow (secondary amenorrhoea or secondary hypomenorrhoe) after trauma to the uterine cavity due to pregnancy related surgical procedure with the presence of intrauterine adhesions with a previous history of normal menstrual blood flow.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Patients with a suspected AS due to tuberculosis or schitsosomiasis.
- Patients with an uncorrected anovulation, amenorrhoe or oligomenorrhoe previous to the AS
- Patients with suspected AS due to hysteroscopic surgery with the use of electrocoagulation (used in fibroid or polyp surgery)
- Patients with congenital uterine anomalies
- Patients with contraindications for a surgical adhesiolysis
- Patients who do not master the Dutch or English language.
- Patients who are younger than 18 years of age or mentally incompetent.
- Patients with contraindications for estrogen and or gestagen
-Patients who use hormonal suppletion
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL9655 |
| CCMO | NL41190.094.13 |
| OMON | NL-OMON45234 |