Linked Color Imaging versus high-definition white light endoscopy for the detection of polyps in patients with Lynch syndrome.
An international, multicenter, parallel randomized controlled trial.

Rationale: Linked Color Imaging is a push-button endoscopic imaging technique developed to enhance the visibility of the vasculature and architecture of the mucosal surface by narrowing the spectrum of absorbed light. Compared to High-Definition White Light Endoscopy, mucosal surface patterns are better visualized and this could potentially increase the detection of polyps by improving the visibility of colorectal polyps. Patients with Lynch syndrome have accelerated carcinogenesis and even the smallest polyps have malignant potential. Increasing polyp detection rates with new imaging techniques is therefore of importance.

Objective: To compare polyp detection rates of Linked Color Imaging with High-Definition White Light Endoscopy during surveillance colonoscopy in Lynch patients

Study design: international, multicentre, parallel, randomized controlled trial

Study population: Patients diagnosed with Lynch syndrome aged ≥ 18 years old

Intervention: Linked Color Imaging colonoscopy or High-Definition White Light Endoscopy

Main study parameters/endpoints: Polyp detection rate of Linked Color Imaging versus High-Definition White Light Endoscopy

Nature and extent of the burden and risks associated with participation, benefit
and group relatedness: Each colonoscopy is associated with a small, but not negligible
risk of bleeding (~1.5%) or perforation (~0.1%). The use of LCI does not increase the
risk of endoscopy.

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Linked Color Imaging versus high-definition white light endoscopy