DUET II

1. Patients with acute and sub-acute (less than 7 weeks) thrombosed infra-inguinal native arteries with ischemic complaints.

2. Patients with acute and sub-acute (less than 7 weeks) thrombosed infra-inguinal venous or prosthetic bypass grafts with ischemic complaints.

3. Limb ischemia class I and IIa according to the Rutherford classification (see below).

4. Patients >18 years and <85 years old.

5. Patients understand the nature of the procedure and provide written informed consent, prior to enrolment in the study

1. Patients with isolated common femoral artery thrombosis including the origin of the superficial femoral artery and/ or profunda femoral artery

2. Patients with clinical complaints of lower limb ischemia due to thrombosis of femoro-popliteal or femoro-crural native arteries or femoro-popliteal and femoro-crural bypass grafts >7 weeks

3. Patients with acute lower limb ischemia class IIb and III according to the Rutherford classification (see below)

4. Patients for whom antiplatelet therapy, anticoagulants or thrombolytic drugs are contraindicated

5. Recent (< 6 weeks) ischemic stroke or cerebral bleeding

6. Patients with recent (<6 weeks) surgery

7. Severe hypertension (diastolic blood pressure >110 mmHg, systolic blood pressure >200 mmHg)

8. Current malignancy

9. Patients with a history of prior life-threatening contrast medium reaction

10. Patients with uncorrected bleeding disorders (GI ulcera, mennorrhagia, liver failure)

11. Female patients of child bearing age not taking adequate contraceptives or currently breastfeeding

12. Pregnancy

13. Any patient considered being hemodynamically unstable at onset of procedure

14. Patients refusing treatment

15. Patients currently participating in another investigational drug or device study that have not completed the entire follow up period

16. Patients < 18 years or >85 years old

17. Severe co-morbid condition with life expectancy < 1 month