Critical illness, along with the lack of zeitgebers on the PICU environment, and iatrogenic influences like medication and procedures, results in disturbed circadian rhythms in critically ill children, which is important for their recovery.
ID
Bron
Verkorte titel
Aandoening
- Blootstellingen, chemische letsels en vergiftiging
Aandoening
Critical illness in general
Betreft onderzoek met
Ondersteuning
Onderzoeksproduct en/of interventie
- Overige
Uitkomstmaten
Primaire uitkomstmaten
To describe the distributions of rhythmic parameters in the paediatric ICU and their evolution during PICU stay.
Achtergrond van het onderzoek
Many processes in the human body show variations during every 24 hours, which is called the circadian rhythm. This rhythm is vital for normal homeostasis. In critically-ill adults circadian disturbances have been associated with increased sepsis severity and length of ICU stay, whereas in children little research has been performed. The intensive care unit necessitates a multi-faceted approach in the study of circadian rhythms, although this approach has not been used yet. This study will assess the status of the circadian rhythm of critically-ill children in biomarkers, vital signs, sleep, and gene expression, along with its role in critical illness.
Doel van het onderzoek
Critical illness, along with the lack of zeitgebers on the PICU environment, and iatrogenic influences like medication and procedures, results in disturbed circadian rhythms in critically ill children, which is important for their recovery.
Onderzoeksopzet
PICU admission
Onderzoeksproduct en/of interventie
None
Algemeen / deelnemers
Wetenschappers
Leeftijd
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- All children with an expected PICU-stay of at least two days.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Preterm, i.e. postconceptional age of <37 weeks, on admission - Syndrome associated with severe mental retardation, except for trisomy 21 - Hydrocortison use in the 3 days prior to admission - Melatonin use within 24 hours prior to admission - Transfer from another PICU or NICU - Weight < 2.0 kg - Expected not to receive arterial line during study period - Previously included in this Critical Clock study
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
Toelichting
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL8533 |
| CCMO | NL72597.078.20 |
| OMON | NL-OMON49654 |