Ledipasvir and sofosbuvir for 8 weeks for the treatment of chronic hepatitis C genotype 4 in patients without cirrhosis.

1. ¡Ý18 years

2. Chronic HCV genotype 4 infection according to definition mentioned below

3. F0-3 with biopsy or fibroscan result (stiffness <12.5 kPa) ¡Ü24 months old for F0-2 and <12 months old for F3

4. HVC viral load < 10 million IU/ml, ¡Ü6 months old.

Definition of chronic hepatitis C infection: The diagnosis of chronic hepatitis C is based on the detection of both anti-HCV antibodies or HCV RNA present for more than 6 months. Since, in the case of a newly acquired HCV infection, spontaneous viral clearance is rare after the first 6months of infection, the diagnosis of chronic hepatitis C can be made at that time (as stated in the EASL clinical practice guideline ¡°Recommendations on treatment of hepatitis C 2015¡±).

1. HCV viral load >10 million IU/ml

2. Fibroscan >12.5 Kpa or F4 on liver biopsy or signs of portal hypertension or liver cirrhosis on imaging

3. Disallowed co-medication that cannot be stopped or replaced: Therefore ALL co-medication, including over-the-counter drugs should be checked for potential drug-drug interactions using the summary of product characteristics (appendix A). When in doubt about drug-drug interactions, contact the coordinating investigator.

4. eGFR < 30 ml/min

5. Previous therapy with any DAA for current HCV genotype 4 infection