To develop an innovative personalized prognostic model for outcome of pediatric TBI in crucial domains of child development (i.e. motor, neurocognitive, and, behavioral functioning), using a unique combination of demographic, pre-injury and clinical…
ID
Bron
Verkorte titel
Aandoening
Children with Traumatic Brain Injury
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Motor functioning, neurocognitive functioning and behavioral functioning will be used to construct the overall outcome score
Achtergrond van het onderzoek
Outcome prediction in children with TBI falls short, preventing clinicians to tailor medical decision making to the child’s individual risk profile. This contributes to overtreatment (i.e. unnecessary follow-up) and undertreatment (i.e. undetected impairment). We aim to develop an innovative personalized prognostic model for outcome of children with TBI, using a unique combination of demographic, pre-injury and clinical predictors. The value of innovative MRI techniques and promising machine learning algorithms will be investigated for prognostic purposes that can be clinically implemented.
Doel van het onderzoek
To develop an innovative personalized prognostic model for outcome of pediatric TBI in crucial domains of child development (i.e. motor, neurocognitive, and, behavioral functioning), using a unique combination of demographic, pre-injury and clinical predictors. The prognostic model can importantly contribute to the planning of early rehabilitation and follow-up, preventing unnecessary care for children with good recovery and facilitating swift and adequate monitoring and treatment of children with high-risks of adverse outcome.
Onderzoeksopzet
T0; hospital admission (demographic predictors, pre-injury predictors, clincial predictors)
T1; 1 month post-injury only for children aged 8 years and older (brain strucuture and function assessed with MRI)
T2; 6 months post-injury (motor, neurocognitive, and school functioning as well as brain function assessed with EEG)
Algemeen / deelnemers
Wetenschappers
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. 4-18 years;
2. Fluent Dutch speaker;
3. Inhabitant of The Netherlands;
4. Hospital admission for mild to severe TBI.
5. No documented and/or parent-reported diagnosis of a neurological disorder (other than TBI).
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Absence or withdrawal of written informed consent;
2. Severe motor disability that interferes with outcome assessment at time of assessment;
3. Inability to comprehend testing instructions at time of assessment;
4. Somatic disorders unrelated to TBI and possibly affecting the outcome assessments at time of assessment.
Opzet
Deelname
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Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL9051 |
| CCMO | NL71283.018.19 |
| OMON | NL-OMON54521 |