The objective of the MORE studies is to select and validate a biomarker profile predictive for the response to weekly paclitaxel and carboplatin chemotherapy concomitant with radiotherapy in patients with esophageal cancer. In the MORE-1 pilot…
ID
Bron
Verkorte titel
Aandoening
non-metastastatic esophageal cancer
niet uitgezaaid slokdarmkanker
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The main study parameters are differences in kinetic profile and/or genetic profile between patients with and without a pathologic complete response after chemo radiation.
Achtergrond van het onderzoek
Single-centre study
Doel van het onderzoek
The objective of the MORE studies is to select and validate a biomarker profile predictive for the response to weekly paclitaxel and carboplatin chemotherapy concomitant with radiotherapy in patients with esophageal cancer.
In the MORE-1 pilot study candidate biomarkers are selected using a multimodal approach combining genomics (next generation sequencing) and proteonomics/kinomics (kinase activity profiling). The objective of the MORE-2 study is to validate the classifier that is developed in the MORE-1 study in patients treated with definitive chemo radiation (without surgery).
Onderzoeksopzet
response after surgery en 2 year follow-up for diseasefree survival and overall survival
Onderzoeksproduct en/of interventie
Staging and treatment will be performed according to local and Dutch treatment guidelines. During the regular endoscopic ultrasonography (EUS) staging procedure 4 extra biopsies for biomarker testing will be taken from the primary esophageal tumor. One extra blood sample for genetic analyses purposes will be collected combined with a regular chemotherapy associated blood collection.
Algemeen / deelnemers
Wetenschappers
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
All patients referred to MCL with pathologically proven carcinoma of the esophagus and without distant metastases will be asked to participate
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
none
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4821 |
| NTR-old | NTR5323 |
| CCMO | NL53633.099.15 |
| OMON | NL-OMON42549 |